Amyloid-beta clearance in Alzheimer's disease
Material type: ArticleLanguage: English Publication details: Frontiers Media SA 2015Description: 1 electronic resource (111 p.)ISBN:- 978-2-88919-443-8
- 9782889194438
Item type | Home library | Collection | Call number | Materials specified | Status | Date due | Barcode | |
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Electronic-Books | OPJGU Sonepat- Campus | E-Books Open Access | Available |
Open Access star Unrestricted online access
Strong evidence continues to accumulate indicating that amyloid-beta (Aß) is a central part of Alzheimer's disease (AD) pathogenesis in spite of the negative evidence coming from failed clinical trials. Therefore, mechanisms of clearance of Aß are of great interest in understanding AD pathogenesis and the development of effective treatments. This topic focuses on the issues related to Aß clearance in AD. The topics covered include proteases that degrade Aß and their localization, regulation, and functions. This topic also covers issues related to clearance through uptake by glia and through low-density lipoprotein (LDL) receptor mediated mechanisms. Signal transduction related to AD pathology and clearance is also addressed. Finally, immunotherapy and other novel therapeutic approaches are discussed.
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