Amyloid-beta clearance in Alzheimer's disease
Robert Marr
Amyloid-beta clearance in Alzheimer's disease - Frontiers Media SA 2015 - 1 electronic resource (111 p.)
Open Access
Strong evidence continues to accumulate indicating that amyloid-beta (Aß) is a central part of Alzheimer's disease (AD) pathogenesis in spite of the negative evidence coming from failed clinical trials. Therefore, mechanisms of clearance of Aß are of great interest in understanding AD pathogenesis and the development of effective treatments. This topic focuses on the issues related to Aß clearance in AD. The topics covered include proteases that degrade Aß and their localization, regulation, and functions. This topic also covers issues related to clearance through uptake by glia and through low-density lipoprotein (LDL) receptor mediated mechanisms. Signal transduction related to AD pathology and clearance is also addressed. Finally, immunotherapy and other novel therapeutic approaches are discussed.
Creative Commons
English
978-2-88919-443-8 9782889194438
10.3389/978-2-88919-443-8 doi
amyloid-beta Signal Transduction Proteases LDL receptors Clearance Alzheimer's disease
Amyloid-beta clearance in Alzheimer's disease - Frontiers Media SA 2015 - 1 electronic resource (111 p.)
Open Access
Strong evidence continues to accumulate indicating that amyloid-beta (Aß) is a central part of Alzheimer's disease (AD) pathogenesis in spite of the negative evidence coming from failed clinical trials. Therefore, mechanisms of clearance of Aß are of great interest in understanding AD pathogenesis and the development of effective treatments. This topic focuses on the issues related to Aß clearance in AD. The topics covered include proteases that degrade Aß and their localization, regulation, and functions. This topic also covers issues related to clearance through uptake by glia and through low-density lipoprotein (LDL) receptor mediated mechanisms. Signal transduction related to AD pathology and clearance is also addressed. Finally, immunotherapy and other novel therapeutic approaches are discussed.
Creative Commons
English
978-2-88919-443-8 9782889194438
10.3389/978-2-88919-443-8 doi
amyloid-beta Signal Transduction Proteases LDL receptors Clearance Alzheimer's disease