Biomarkers of Environmental Toxicants
LU, Kun
Biomarkers of Environmental Toxicants - Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2020 - 1 electronic resource (292 p.)
Open Access
Biomarkers of environmental toxicants are measures of exposures, some of which can serve to assess disease risk and inter-individual susceptibilities. Metabolites, protein and DNA adducts also serve to elucidate the mechanisms of the bioactivation and detoxication of reactive toxicant intermediates. Some environmental chemicals act as modulators of gene and protein activity, and induce the dysbiosis of the microbiome, which impacts the metabolome and overall health. In this Special Issue on "Biomarkers of Environmental Toxicants", review articles and original research studies are featured, covering the latest bioanalytical, biochemical and mass spectrometry-based technologies, to monitor exposures through targeted and non-targeted methods, and mechanistic studies that examine the biological effects of environmental toxicants in cells and humans. Diverse topics, such as exposome, microbiome, DNA/protein adducts and t-RNA modifications, as well as important environment toxicants, including heavy metals, benzene, phthalates, aldehydes, glycidol, tobacco smoke and aristolochic acids, are covered. Novel analytical methods, such as protein adductomics, DNA adduct analysis in formalin-fixed paraffin-embedded tissues, site-specific mutagenesis assay and accelerator mass spectrometry, are also included. This collection provides a valuable update of the most recent biochemical and analytical tools that employ biomarkers in toxicology research, biomarker discovery, and exposure and risk assessment in population-based studies.
Creative Commons
English
books978-3-03936-737-5 9783039367368 9783039367375
10.3390/books978-3-03936-737-5 doi
Medicine
manganese lead cadmium arsenic hair children environment carcinogen DNA adducts biomonitoring formalin-fixed paraffin-embedded tissues biomarker mass spectrometry human biomonitoring urine non-occupational exposure S-phenyl-mercapturic acid HPLC-MS/MS glycidol Hb adduct N-(2.3-dihydroxypropyl)valine in vivo cancer risk UPLC/MS/MS aristolochic acids food contamination environmental pollution root uptake aristolochic acid nephropathy Balkan endemic nephropathy chronic kidney disease tobacco smoke human carcinogen biomarkers epitranscriptomics tRNA modifications stress response mechanisms codon-biased translation phthalate DEHP human exposure toxicity reproductive accelerator mass spectrometry cavity ring down spectrophotometry radiocarbon naphthalene benzo[a]pyrene cell turnover triclocarban metastasis haemoglobin albumin protein adducts aldehydes genotoxicity cancer diseases oxidative stress exposure biomarkers high-resolution mass spectrometry data-dependent profiling derivatization biological fluids isotope labeling DNA lesion DNA damage shuttle vector technique replication block mutagenicity mutational spectrum mutational signature DNA repair DNA adduct bypass site-specific mutagenesis chemical exposome environmental monitoring disease bioinformatics gut microbiome chemical toxicity n/a
Biomarkers of Environmental Toxicants - Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2020 - 1 electronic resource (292 p.)
Open Access
Biomarkers of environmental toxicants are measures of exposures, some of which can serve to assess disease risk and inter-individual susceptibilities. Metabolites, protein and DNA adducts also serve to elucidate the mechanisms of the bioactivation and detoxication of reactive toxicant intermediates. Some environmental chemicals act as modulators of gene and protein activity, and induce the dysbiosis of the microbiome, which impacts the metabolome and overall health. In this Special Issue on "Biomarkers of Environmental Toxicants", review articles and original research studies are featured, covering the latest bioanalytical, biochemical and mass spectrometry-based technologies, to monitor exposures through targeted and non-targeted methods, and mechanistic studies that examine the biological effects of environmental toxicants in cells and humans. Diverse topics, such as exposome, microbiome, DNA/protein adducts and t-RNA modifications, as well as important environment toxicants, including heavy metals, benzene, phthalates, aldehydes, glycidol, tobacco smoke and aristolochic acids, are covered. Novel analytical methods, such as protein adductomics, DNA adduct analysis in formalin-fixed paraffin-embedded tissues, site-specific mutagenesis assay and accelerator mass spectrometry, are also included. This collection provides a valuable update of the most recent biochemical and analytical tools that employ biomarkers in toxicology research, biomarker discovery, and exposure and risk assessment in population-based studies.
Creative Commons
English
books978-3-03936-737-5 9783039367368 9783039367375
10.3390/books978-3-03936-737-5 doi
Medicine
manganese lead cadmium arsenic hair children environment carcinogen DNA adducts biomonitoring formalin-fixed paraffin-embedded tissues biomarker mass spectrometry human biomonitoring urine non-occupational exposure S-phenyl-mercapturic acid HPLC-MS/MS glycidol Hb adduct N-(2.3-dihydroxypropyl)valine in vivo cancer risk UPLC/MS/MS aristolochic acids food contamination environmental pollution root uptake aristolochic acid nephropathy Balkan endemic nephropathy chronic kidney disease tobacco smoke human carcinogen biomarkers epitranscriptomics tRNA modifications stress response mechanisms codon-biased translation phthalate DEHP human exposure toxicity reproductive accelerator mass spectrometry cavity ring down spectrophotometry radiocarbon naphthalene benzo[a]pyrene cell turnover triclocarban metastasis haemoglobin albumin protein adducts aldehydes genotoxicity cancer diseases oxidative stress exposure biomarkers high-resolution mass spectrometry data-dependent profiling derivatization biological fluids isotope labeling DNA lesion DNA damage shuttle vector technique replication block mutagenicity mutational spectrum mutational signature DNA repair DNA adduct bypass site-specific mutagenesis chemical exposome environmental monitoring disease bioinformatics gut microbiome chemical toxicity n/a