000 | 07051naaaa2201933uu 4500 | ||
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001 | https://directory.doabooks.org/handle/20.500.12854/69023 | ||
005 | 20220714192833.0 | ||
020 | _abooks978-3-03936-385-8 | ||
020 | _a9783039363841 | ||
020 | _a9783039363858 | ||
024 | 7 |
_a10.3390/books978-3-03936-385-8 _cdoi |
|
041 | 0 | _aEnglish | |
042 | _adc | ||
072 | 7 |
_aM _2bicssc |
|
100 | 1 |
_aJavadov, Sabzali _4edt _91617948 |
|
700 | 1 |
_aKozlov, Andrey V. _4edt _91617949 |
|
700 | 1 |
_aCamara, Amadou K.S. _4edt _91617950 |
|
700 | 1 |
_aJavadov, Sabzali _4oth _91617948 |
|
700 | 1 |
_aKozlov, Andrey V. _4oth _91617949 |
|
700 | 1 |
_aCamara, Amadou K.S. _4oth _91617950 |
|
245 | 1 | 0 | _aMitochondria in Health and Diseases |
260 |
_aBasel, Switzerland _bMDPI - Multidisciplinary Digital Publishing Institute _c2020 |
||
300 | _a1 electronic resource (434 p.) | ||
506 | 0 |
_aOpen Access _2star _fUnrestricted online access |
|
520 | _aMitochondria are subcellular organelles evolved by the endosymbiosis of bacteria with eukaryotic cells. They are the main source of ATP in the cell and engaged in other aspects of cell metabolism and cell function, including the regulation of ion homeostasis, cell growth, redox status, and cell signaling. Due to their central role in cell life and death, mitochondria are also involved in the pathogenesis and progression of human diseases/conditions, including neurodegenerative and cardiovascular disorders, cancer, diabetes, inflammation, and aging. However, despite the increasing number of studies, precise mechanisms whereby mitochondria are involved in the regulation of basic physiological functions, as well as their role in the cell under pathophysiological conditions, remain unknown. A lack of in-depth knowledge of the regulatory mechanisms of mitochondrial metabolism and function, as well as interplay between the factors that transform the organelle from its role in pro-survival to pro-death, have hindered the development of new mitochondria-targeted pharmacological and conditional approaches for the treatment of human diseases. This book highlights the latest achievements in elucidating the role of mitochondria under physiological conditions, in various cell/animal models of human diseases, and in patients. | ||
540 |
_aCreative Commons _fhttps://creativecommons.org/licenses/by/4.0/ _2cc _4https://creativecommons.org/licenses/by/4.0/ |
||
546 | _aEnglish | ||
650 | 7 |
_aMedicine _2bicssc |
|
653 | _ahypoglycemia | ||
653 | _asodium dichloroacetate | ||
653 | _apyruvate dehydrogenase kinase | ||
653 | _apyruvate dehydrogenase | ||
653 | _aoxidative stress | ||
653 | _aneuron death | ||
653 | _acholangiocellular carcinoma | ||
653 | _amitochondria | ||
653 | _aenergy metabolism | ||
653 | _aoxidative phosphorylation | ||
653 | _a4-HNE | ||
653 | _aDRP1 | ||
653 | _aERK1/2 | ||
653 | _ahippocampus | ||
653 | _aJNK | ||
653 | _amitochondrial dynamics | ||
653 | _aPKA | ||
653 | _aprotein phosphatases | ||
653 | _aTUNEL | ||
653 | _aDDE | ||
653 | _ahigh-fat diet | ||
653 | _amitochondrial UCP2 | ||
653 | _aROS | ||
653 | _aantioxidant system | ||
653 | _auncoupling protein | ||
653 | _amitochondria: energy metabolism | ||
653 | _alipid handling | ||
653 | _afatty acid oxidation | ||
653 | _apotassium channel | ||
653 | _areactive oxygen species | ||
653 | _aantioxidants | ||
653 | _alife span | ||
653 | _aaging | ||
653 | _aBKCa channels | ||
653 | _apravastatin | ||
653 | _agemfibrozil | ||
653 | _aliver | ||
653 | _acolon | ||
653 | _amitochondrial function | ||
653 | _acyclosporin A | ||
653 | _amitochondria calcium buffering | ||
653 | _amitochondria bioenergetics | ||
653 | _amitochondria permeability transition pore | ||
653 | _ainorganic phosphate | ||
653 | _ahepatic fibrogenesis | ||
653 | _aHtrA2/Omi | ||
653 | _areactive oxygen species stress | ||
653 | _amitochondrial homeostasis | ||
653 | _acomplex I (CI) deficiency | ||
653 | _ametabolome and proteome profiling | ||
653 | _areactive oxygen species (ROS) | ||
653 | _arespirasome assembly | ||
653 | _aelectron tunneling (ET) | ||
653 | _aperilipin 5 | ||
653 | _alipid droplet | ||
653 | _aH9c2 cardiomyoblasts | ||
653 | _aadenine nucleotide translocase | ||
653 | _arespiratory supercomplexes | ||
653 | _aETC complexes | ||
653 | _adentate granule cell | ||
653 | _aepilepsy | ||
653 | _ahyperforin | ||
653 | _aLONP1 | ||
653 | _aneuroprotection | ||
653 | _apilocarpine | ||
653 | _aseizure | ||
653 | _asiRNA | ||
653 | _acardioprotection | ||
653 | _amitochondrial permeability transition pores | ||
653 | _amitochondrial connexin 43 | ||
653 | _acardiolipin | ||
653 | _airon overload | ||
653 | _ahepcidin | ||
653 | _atransferrin | ||
653 | _aferritin | ||
653 | _aZIP | ||
653 | _ainflammation | ||
653 | _amtDNA | ||
653 | _amitochondrial dysfunction | ||
653 | _amuscle aging | ||
653 | _aphysical performance | ||
653 | _aLHON | ||
653 | _aSiberian population | ||
653 | _aancient mutation | ||
653 | _aspecific genetic background | ||
653 | _aapoptosis | ||
653 | _ahuman amniotic membrane | ||
653 | _amitochondrial cell death | ||
653 | _aBAX | ||
653 | _aBCL-2 | ||
653 | _atensile strength | ||
653 | _amitochondrial gene expression | ||
653 | _amtDNA transcription | ||
653 | _amtRNA | ||
653 | _apost-transcriptional mtRNA processing | ||
653 | _adsRNA | ||
653 | _ainnate immunity | ||
653 | _ainterferon response | ||
653 | _aamino acid neurotransmitter | ||
653 | _acerebellar amino acid metabolism | ||
653 | _ahypoxia | ||
653 | _a2-oxoglutarate dehydrogenase | ||
653 | _atricarboxylic acid cycle | ||
653 | _aheart | ||
653 | _acytoskeletal proteins | ||
653 | _amitochondrial interactions | ||
653 | _aplectin | ||
653 | _atubulin beta | ||
653 | _asignaling | ||
653 | _aGW9662 | ||
653 | _aischemia reperfusion injury | ||
653 | _aLangendorff | ||
653 | _amyocardial | ||
653 | _apioglitazone | ||
653 | _aredox state | ||
653 | _arosiglitazone | ||
653 | _aTZD | ||
653 | _auncoupling | ||
653 | _aADP/ATP carrier | ||
653 | _aKmADP | ||
653 | _adextran | ||
653 | _amorphology | ||
653 | _acardiomyocytes | ||
653 | _atelomere length | ||
653 | _atelomerase activity | ||
653 | _adevelopment | ||
653 | _aregeneration | ||
653 | _aintranuclear mitochondria | ||
653 | _ahealthy cells | ||
653 | _aelectron and confocal microscopy | ||
653 | _asignaling pathways | ||
653 | _aion homeostasis | ||
653 | _ahuman diseases | ||
856 | 4 | 0 |
_awww.oapen.org _uhttps://mdpi.com/books/pdfview/book/2792 _70 _zDOAB: download the publication |
856 | 4 | 0 |
_awww.oapen.org _uhttps://directory.doabooks.org/handle/20.500.12854/69023 _70 _zDOAB: description of the publication |
999 |
_c3016719 _d3016719 |