| 000 | 03887naaaa2200361uu 4500 | ||
|---|---|---|---|
| 001 | https://directory.doabooks.org/handle/20.500.12854/41778 | ||
| 005 | 20220714184130.0 | ||
| 020 | _a978-2-88919-931-0 | ||
| 020 | _a9782889199310 | ||
| 024 | 7 |
_a10.3389/978-2-88919-931-0 _cdoi |
|
| 041 | 0 | _aEnglish | |
| 042 | _adc | ||
| 100 | 1 |
_aHiroshi Nikaido _4auth _91604881 |
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| 700 | 1 |
_aAttilio Vittorio Vargiu _4auth _91604882 |
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| 700 | 1 |
_aKlaas Martinus Pos _4auth _91604883 |
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| 700 | 1 |
_aKeith Poole _4auth _91604884 |
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| 245 | 1 | 0 | _aBad Bugs in the XXIst Century: Resistance Mediated by Multi-Drug Efflux Pumps in Gram-Negative Bacteria |
| 260 |
_bFrontiers Media SA _c2016 |
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| 300 | _a1 electronic resource (193 p.) | ||
| 506 | 0 |
_aOpen Access _2star _fUnrestricted online access |
|
| 520 | _aThe discovery of antibiotics represented a key milestone in the history of medicine. However, with the rise of these life-saving drugs came the awareness that bacteria deploy defence mechanisms to resist these antibiotics, and they are good at it. Today, we appear at a crossroads between discovery of new potent drugs and omni-resistant superbugs. Moreover, the misuse of antibiotics in different industries has increased the rate of resistance development by providing permanent selective pressure and, subsequently, enrichment of multidrug resistant pathogens. As a result, antimicrobial resistance has now become an urgent threat to public health worldwide (http://www.who.int/drugresistance/documents/surveillancereport/en/). The development of multidrug resistance (MDR) in an increasing number of pathogens, including Pseudomonas, Acinetobacter, Klebsiella, Salmonella, Burkholderia, and other Gram-negative bacteria is a most severe issue. Membrane efflux pump complexes of the Resistance-Nodulation-cell Division (RND) superfamily play a key role in the development of MDR in these bacteria. RND pumps, together with other transporters, contribute to intrinsic and acquired resistance to most, if not all, of the antimicrobial compounds available in our drug arsenal. Given the enormous drug polyspecificity of MDR efflux pumps, studies on their mechanism of action are extremely challenging, and this has negatively impacted both the development of new antibiotics that are able to evade these efflux pumps as well as the design of pump inhibitors. The collection of articles in this eBook, published as a Research Topic in Frontiers in Microbiology, section of Antimicrobials, Resistance, and Chemotherapy, aims to update the reader about the latest advances on the structure and function of RND efflux transporters, their roles in the overall multidrug resistance phenotype of Gram-negative pathogens, and on strategies to inhibit their activities. A deeper understanding of the mechanisms by which RND efflux pumps, alone or synergistically with other efflux pumps, are able to limit the concentration of antimicrobial compounds inside the bacterial cell, may pave the way for new, more directed, inhibitor and antibiotic design to ultimately overcome antimicrobial resistance by Gram-negatives. | ||
| 540 |
_aCreative Commons _fhttps://creativecommons.org/licenses/by/4.0/ _2cc _4https://creativecommons.org/licenses/by/4.0/ |
||
| 546 | _aEnglish | ||
| 653 | _aResistance-Nodulation Division transporters | ||
| 653 | _amulti-drug-resistant pathogens | ||
| 653 | _aantibiotic resistance | ||
| 653 | _aGram-Negative Bacteria | ||
| 653 | _abacterial resistance mechanisms | ||
| 653 | _aSuperbugs | ||
| 653 | _aefflux pumps | ||
| 856 | 4 | 0 |
_awww.oapen.org _uhttp://journal.frontiersin.org/researchtopic/2904/bad-bugs-in-the-xxist-century-resistance-mediated-by-multi-drug-efflux-pumps-in-gram-negative-bacter _70 _zDOAB: download the publication |
| 856 | 4 | 0 |
_awww.oapen.org _uhttps://directory.doabooks.org/handle/20.500.12854/41778 _70 _zDOAB: description of the publication |
| 999 |
_c3005586 _d3005586 |
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