Epilepsy : a century of discovery / Ramon Edmundo D. Bautista, editor.

Includes bibliographical references and index.

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EPILEPSY: A CENTURY OF DISCOVERY; EPILEPSY: A CENTURY OF DISCOVERY; Library of Congress Cataloging-in-Publication Data; Contents; Preface; References; About the Contributors; Chapter I: Basic Mechanisms of the Epileptic Process; Abstract; Introduction; Electrical Properties of Epileptic Neurons; Ion Channels and Channelopathies; Voltage Gated Potassium Channels; Voltage Gated Sodium Channels; Voltage Gated Calcium Channels; Voltage Gated Chloride Channels; Neurotransmitter Systems and Receptors; GABAergic System; Glutaminergic System; Other Neurotransmitter Systems.

Cortical Structure and LesionsDevelopmental Lesions; Tumours; Acquired Insults; The Hippocampus and Epilepsy; Neural Networks and Epilepsy; The Thalamocortical Network; The Medial Temporal /Limbic System; Transition from the Interictal to the Ictal State; Conclusion; References; Chapter II: Epilepsy: Classification, Aetiology and Management; Abstract; Introduction; Incidence and Prevalence; Classification of Seizures and Epilepsies; Partial Seizures; Generalised Seizures; Epilepsy Syndromes; Aetiology of Epilepsy; Treatment of Epilepsy; Anti Epileptic Drugs; Surgery.

Side Effects and Cognitive Dysfunction Related to AEDsConclusion; References; Chapter III: Anti-Epileptic Drugs: Behavior and Cognition; Abstract; 1. Introduction; Pharmacological Treatments for Epilepsy; Mechanisms of Action of Anti-epileptic Drugs; Factors Influencing Prescribing in Epilepsy; 2. Cognitive Effects of Anti-Epileptic Drugs; Older AEDs; Newer AEDs; Summary; 3. Behavioral Effects of Anti-Epileptic Drugs; Older AEDs; Newer AEDs; Summary; Conclusion; Discussion of Study Findings; Limitations and Recommendations for Future Research; References.

Chapter IV: Clinical Neurophysiology: Past, Present, and FutureAbstract; Introduction; History; EEG Findings in Epilepsy; Pathogenesis of Epileptiform Activity; Utility of Scalp EEG in Epilepsy; Dipole Modeling; Magnetoencephalography; Intracranial EEG Data; Mesial Temporal Epilepsy; Neocortical Epilepsy; Cortical Stimulation; Intraoperative Electrocorticography; High-Frequency Oscillations; Seizure Prediction; Conclusion; References; Chapter V: Neuroimaging in Epilepsy; Abstract; Introduction.

The Use of Conventional Radiographyand Cranial Computed Tomography (CT) Scan in the Evaluation of New Onset SeizureStructural Magnetic Resonance Imaging (MRI); Diffusion Tensor Imaging (DTI) and Tractography; Magnetic Resonance Spectroscopy (MRS); Functional MRI; Positron Emission Tomography (PET); PET Scanning of the Serotonin Receptors; Subtraction Ictal SPECT Co-Registered to MRI (SISCOM); Conclusion; References; Chapter VI: Understanding Human Neurophysiology Through Epilepsy Surgery; Abstract; Introduction; Early Functional Localization; Electrocortical Stimulation Mapping.

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