Modern concepts in angiogenesis / edited by Michael Simons, Gabor M. Rubanyi.

Includes bibliographical references and index.

Print version record.

This volume addresses current emerging concepts in the field of angiogenesis, including important angiogenesis modifiers which are essential in combination with growth factors (VEGF and FGF) for the physiological process and also for therapeutic applications. It covers many of the lesser discussed areas including blood vessel growth guidance (interactions with CNS) as well as emerging practical applications of these concepts. The book comprises in-depth reviews by leading experts in several major areas: recent basic science discoveries about angiogenesis modifiers (semaphorins, ephrins and nitric oxide, for which the Nobel Prize was awarded); arterial guidance; clinical applications of new angiogenic factors (HGF HIF and NOS); and basic and clinical advancement of anti-angiogenic molecules for the treatment of cancer and macular degeneration (tyrosine kinase inhibitors, endostatin and NO). These topics, especially their unique combination presented in this volume, are not found in any other current books on angiogenesis. This makes the book a must-read for readers both interested and actively involved in the most recent advances in basic principles and clinical applications of angiogenesis.

CONTENTS -- Contributors -- Preface -- I Components of Angiogenic Cascades -- Chapter 1. Semaphorins, Plexins and Neuropilins and Their Role in Vasculogenesis and Angiogenesis Gera Neufeld, Niva Shraga-Heled, Tali Lange and Ofra Kessler -- 1. Introduction and Historical Perspective -- 2. The Semaphorins -- 3. The Plexin Receptor Family -- 4. The Neuropilins -- 5. Vascular Endothelial Growth Factors and Their Receptors -- 6. Signal Transduction by Neuropilins -- 7. The Role of the Neuropilins in the Regulation of Vasculogenesis and Angiogenesis

8. Modulation of Angiogenesis by Semaphorins that Bind Directly to PlexinsAcknowledgments -- References -- Chapter 2. EPH Receptors and Ephrins Elena B. Pasquale -- 1. Introduction -- 1.1. Eph receptor domain structure -- 1.2. The ephrin domain structure -- 1.3. Eph-Ephrin bidirectional signaling at sites of cell-to-cell contact -- 2. Effects on Vascular Cell Behavior and Signaling Pathways -- 2.1. Ephrin-A1 and EphA2 -- 2.2. Ephrin-A1 and EphA4 -- 2.3. Ephrin-B and EphB -- 2.3.1. EphB forward signaling -- 2.3.2. Ephrin-B reverse signaling

2.4. Crosstalk with other angiogenic pathways3. Endothelial Cell Fate -- 4. Angiogenic Remodeling of Embryonic Blood Vessels -- 4.1. Ephrin-A1 and EphA receptors -- 4.2. EphB4 and Ephrin-B2 -- 4.3. Other EphB receptors and Ephrin-Bs -- 5. Lymphatic Vessels -- 6. Adult Vasculature -- 6.1. Quiescent vasculature -- 6.2. Physiological angiogenesis -- 6.3. Inflammation and wound healing -- 6.4. Tumor angiogenesis -- 6.4.1. Ephrin-A1 and EphA2 -- 6.4.2. Ephrin-B2 and EphB4 -- 7. Targeting Eph Receptor-Ephrin Interactions to Modulate Angiogenesis

8. PerspectivesAcknowledgments -- References -- Chapter 3. The FGF Family of Angiogenic Growth Factors Patrick Auguste and Andreas Bikfalvi -- 1. Introduction -- 2. Molecular Mechanisms -- 3. Role in Vascular Development -- 4. FGFs in Tumor Angiogenesis -- 5. Role of FGFs in Developmental and Tumor Lymphangiogenesis -- 6. Role in Repair-Associated Angiogenesis and Ischemia Revascularization -- 7. Conclusion -- Acknowledgments -- References -- Chapter 4. Neuropeptide Y: Neurogenic Mediator of Angiogenesis and Arteriogenesis Joanna B. Kitlinska and Zofia Zukowska

1. The NPY System2. NPY as a Growth Factor for Vascular Cells -- 3. DPPIV: A Molecular Switch of the NPY Angiogenic System -- 4. Downstream Mediators of NPY Actions -- 5. NPY in Revascularization of Ischemic Tissues -- 6. NPY in Wound Healing -- 7. NPY in Adipose Tissue Growth and Obesity -- 8. NPY in Retinopathy -- 9. NPY-Induced Angiogenesis in Angioplasty-Induced Neointima and Atherogenesis -- 10. NPY in Tumor Angiogenesis -- 11. NPY-Mediated Angiogenesis and Neurogenesis -- References

English.

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