Hepatitis B virus : molecular mechanisms in disease and novel strategies for therapy / editors, Rajen Koshy, Wolfgang H. Caselmann.

Contributor(s):

Material type: Text

TextPublication details: London : Imperial College Press ; River Edge, NJ : World Scientific [distributor], 1998.Description: 1 online resource (viii, 328 pages) : illustrationsContent type:

text

Media type:

computer

Carrier type:

online resource

ISBN:

9781848161078
1848161077

Subject(s): Genre/Form:

Electronic books.

Additional physical formats: Print version:: Hepatitis B virus.DDC classification:

616.3/623 22

LOC classification:

QR201.H46 H44 1998eb

NLM classification:

1998 J-003
QW 170

Other classification:

XD 7300

Online resources:

Click here to access online

Contents:

pt. 1. Molecular biology of Hepatitis B virus -- Replication of the Hepatitis B virus genome / Christoph Seeger -- The regulation of Hepatitis B virus gene expression: an overview of the cis- and trans- acting components / Marshall J. Kosovsky -- Animal models and experimental systems in Hepatitis B virus research / Stepahn Schaefer -- pt. 2. Infection and chronic disease -- Natural course of HBV infection / Hubert E. Blum -- Genetic variants of HBV / Tim J. Harrison -- The immunology of chronic hepatitis B / Barbara Rehermann -- pt. 3. Hepatocellular carcinoma -- HBV DNA integration and insertional mutagenesis / Katsuro Koike -- Transactivators of HBV, signal transduction and tumorigenesis / Wolfgang H. Caselmann -- Oncogenes, tumour suppressors and co-factors in hepatocellular carcinoma / Hisaki Nagai -- pt. 4. Rational approaches for the prevention of infection and therapy -- Hepatitis B virus vaccines / Florian Schödel -- Chronic hepatitis B viral infection: cytokines and therapy / Graham R. Foster -- The development of targettable vectors for the liver and prospects for treatment / Ludwig Weiss.

Summary: The book covers both the molecular aspects of hepatitis B virus replication and gene expression in vivo and in model systems, and the clinical impact of genetic variants or immunological response in chronic infection. Major emphasis is laid on the molecular mechanisms underlying hepatitis B virus-associated liver carcinogenesis and their possible relevance to therapy and to the prevention of infection. Rational approaches to design novel vaccines or cytokine treatments, as well as strategies to develop vectors for liver-directed gene therapy, are discussed.

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Item type	Home library	Collection	Call number	Materials specified	Status	Date due	Barcode
Electronic-Books	OPJGU Sonepat- Campus	E-Books EBSCO			Available

Includes bibliographical references and indexes.

Print version record.

The book covers both the molecular aspects of hepatitis B virus replication and gene expression in vivo and in model systems, and the clinical impact of genetic variants or immunological response in chronic infection. Major emphasis is laid on the molecular mechanisms underlying hepatitis B virus-associated liver carcinogenesis and their possible relevance to therapy and to the prevention of infection. Rational approaches to design novel vaccines or cytokine treatments, as well as strategies to develop vectors for liver-directed gene therapy, are discussed.

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