Chemical biology : selected papers of H. Gobind Khorana (with introductions) / H. Gobind Khorana.

Includes bibliographical references.

Development of the chemistry and macromolecular structures of proteins -- Development of the chemistry and macromolecular structures of nucleic acids -- Carbodiimides as synthetic reagents -- Phosphoric acid esters in intermediary metabolism : development of methods for their synthesis -- Chemical synthesis of polynucleotides -- Enzymes that degrade nucleic acids -- The genetic code : (A) specificity in protein synthesis; the transfer ribonucleic acids -- The genetic code : (B) basic features and codon assignments -- The total synthesis of genes -- Gene amplification (PCR) --Bioenergetics : bacteriorhodopsin, a light-driven proton pump -- Har Gobind Khorana [autobiographical statement] -- From carbodiimide to gene synthesis [text of the 13th Feodor Lynen Lecture delivered on January 13, 1981] -- Epilogue.

Print version record.

The first two chapters of this invaluable book trace the developments of the chemistry and macromolecular structures, respectively, of proteins and nuclei acids. Similarly, the introductions to the succeeding chapters review, step by step, the historical landmarks in the topics covered. These include discoveries of biological phosphate esters, nucleotides and nucleotide coenzymes (important in intermediary metabolism), the nature of the genetic material and biological synthesis of proteins, formulation of the problem of the genetic code, and perspectives on bioenergetics. The selected papers il.

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