Cardiac mechano-electric coupling and arrhythmias / Peter Kohl, Frederick Sachs, and Michael R. Franz.

Revised edition of: Cardiac mechano-electric feedback and arrhythmias. 2005.

Includes bibliographical references and index.

Basic science, section I: sub-cellular mechanisms of cardiac mechano-electric coupling -- Evolutionary origins of stretch-activated ion channels -- Stretch-activated channels in the heart -- The mechano-gated K2P channel TREK-1 in the cardiovascular system -- Cell volume-sensitive ion channels and transporters in cardiac myocytes -- The response of cardiac muscle to stretch: calcium and force -- Stretch effects on second messengers -- Functional implications of myocyte architecture -- Mechanical modulation of pacemaker electrophysiology -- Mechano-electric coupling in working cardiomyocytes: diastolic and systolic effects -- Mechano-sensitivity of pulmonary vein cells: implications for atrial arrhythmogenesis -- Heterogeneity of sarcomere length and function as a cause of arrhythmogenic calcium waves -- Cellular mechanisms of arrhythmogenic cardiac alternans -- Remodeling of gap junctions in ventricular myocardium: effects of cell-to-cell adhesion, mediators of hypertrophy and mechanical forces -- The origin of fibroblasts, ECM and potential contributions to cardiac mechano-electric coupling -- Advantages and pitfalls of cell cultures as model systems to study cardiac mechanoelectric coupling -- Activation sequence of cardiac muscle in simplified experimental models: relevance for cardiac mechano electric coupling -- Acute stretch effects on atrial electro-physiology -- Stretch effects on potassium accumulation and alternans in pathological myocardium -- The effects of wall stretch on ventricular conduction and refractoriness in the whole heart -- Mechanical triggers of long-term ventricular electrical remodeling -- Mechanisms of mechanical pre- and postconditioning -- Mechano-electric coupling in chronic atrial fibrillation -- Mechanically induced pulmonary vein ectopy -- insight from animal models -- Regional variation in mechano-electric coupling: the right ventricle -- Mechanical induction of arrhythmia in the ex-situ heart: insight into commotio cordis -- Arrhythmias in murine models of the mechanically impaired heart -- Studying cardiac mechano-sensitivity in man -- Mathematical models of cardiac structure and function: mechanistic insights from models of heart failure -- Mathematical models of human atrial mechano-electrical coupling and arrhythmias -- Mathematical models of ventricular mechano-electric coupling and arrhythmia -- Load dependence of ventricular repolarisation -- Is the U wave in the electrocardiogram a mechanoelectrical phenomenon? -- Mechanical modulation of cardiac function: role of the pericardium -- Mechanically-induced electrical remodelling in human atrium -- Drug effects and atrial fibrillation: potential and limitations -- Stretch as a mechanism linking short- and long-term electrical remodeling in the ventricles.

Volume and pressure overload and ventricular arrhythmogenesis -- Stretch effects on fibrillation dynamics -- Commotio cordis: sudden death from blows to the chest wall -- Repolarization changes in the synchronously and dys-synchronously contracting failing heart -- Ventricular arrhythmias in heart failure: link to hemodynamic load -- Mechanical heterogeneity and aftercontractions as trigger of torsades des pointes -- Stretch-induced arrhythmias in ischaemia -- Antiarrhythmic effects of acute mechanical stimulation -- Termination of arrhythmias by haemodynamic unloading -- Mechanical modulation of defibrillation and resuscitation efficacy -- Anti- and pro-arrhythmic effects of cardiac assist device implantation -- Anti- and pro-arrhythmic effects of cardiac resynchronization therapy -- Evidence for mechano-electric coupling from clinical trials on AF -- Evidence for mechano-electric coupling from clinical trials in heart failure -- Mechano-electrical coupling and the pathogenesis of arrhythmogenic right ventricular cardiomyopathy -- Evidence for mechano-electric coupling from clinical trials on cardiac resynchronization therapy -- Mechano-electric coupling in patients treated with ventricular assist devices: insights from individual cases and clinical trials -- Measuring strain of structural proteins in vivo in real time -- Roles of SAC beyond M-E transaction -- Distributions of myocyte stress, strain and work in normal and infarcted ventricles -- Evolving concepts in measuring ventricular strain in the canine and human hearts: non-invasive imaging -- Evolving concepts in measuring ventricular strain in the human heart: impedance measurements -- Mechanosensitive channel blockers: a new class of antiarrhythmic drugs?

Print version record.

Ranging from stretch-activated ion channels to mechanically induced arrhythmias and mechanical interventions for heart rhythm correction, this new edition offers a thoroughly reviewed compendium of chapters, written by the top-experts in the world on the mechanism and consequences of cardiac mechano-electrical coupling.

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