Molecular pathology : the molecular basis of human disease / edited by William B. Coleman, Gregory J. Tsongalis.

Includes index.

Online resource; title from PDF title page (ScienceDirect, viewed October 10, 2017).

Includes bibliographical references and index.

Molecular mechanisms of cell death / John J. Lemasters -- Acute and chronic inflammation induces disease pathogenesis / Catherine Ptaschinski and Nichlas W. Lukacs -- Infection and host response / Susan L. Fink and Sheldon Campbell -- Neoplasia / William B. Coleman -- Basic concepts in human molecular genetics / Christine M. Koellner, Kara A. Mesink, and W. Edward Highsmith Jr. -- The human genome: understanding human disease in the post-genomic era / William B. Coleman -- The human transcriptome: implications for understanding, diagnosing, and treating human disease / Matthias E. Futschik, Markus Morkel, Reinhold Schäfer, and Christine Sers -- The human epigenome: implications for the understanding of human disease / Manel Esteller -- Clinical proteomics and molecular pathology / Lance A. Liotta, Justin B. Davis, Robin D. Couch, Claudia Fredolini, Weidong Zhou, Emanuel Petricoin, and Virginia Espina -- Integrative systems biology / Gregory J. Tsongalis -- Patholody: the clinical description of human disease / William K. Funkhousser Jr. -- Understanding molecular pathogenesis: the biological basis of human disease and implications for improved treatment of human disease / William B. Coleman and Gregory J. Tsongalis -- Integration of molecular and cellular pathogenesis: a bioinformativs approach / Jason H. Moore, and Michael D. Feldman -- Molecular basis of cardiovascular disease / Avrum I. Gotlieb -- Molecular basis of hemostatic and thrombotic diseases / Karlyn Martin, Alice D. Ma, and Nigel S. Key -- Molecular basis of lymphoid and myeloid diseases / Joseph R. Biggs and Dong-er Zhang -- Molecular basis of diseases of immunity / David O. Beenhouwer -- Molecular basis of pulmonary disease / Dani S. Zander and Carol F. Farver -- Molecular basis of diseases of the gastrointestinal tract / Antonia R. Sepulveda and Armando J. del Portillo -- Molecular basis of liver disease / Satdarshan P.S. Monga and Jaideep Behari -- Molecular basis of diseases of the exocrine pancreas / Matthias Sendler, Julia Mayerle, and Markus M. Lerch -- Molecular basis of diseases of the endocrine system / Alan L.-Y. Pang and Wai-Yee Chan -- Molecular basis of gynecologic diseases / Samuel C. Mock, Kwong-Kwok Wong, Karen H. Lu, Karl Munger, and Zoltan Nagymanyoki -- Molecular basis of kidney disease / Roderick J. Tan, Sheldon I. Bastacky, and Youhua Liu -- Molecular pathogenesis of prostate cancer / William B. Coleman -- Molecular biology of breast cancer / Philippe Aftimos, Hatem A. Azim Jr., and Christos Sotiriou -- Molecular basis of skin disease / Vesarat Wessagowit -- Molecular basis of bone diseases / Emanuela Galliera and Massimiliano M. Corsi Romanelli -- Molecular basis of diseases of the nervous system / Margaret Flanagan, Joshua A. Sonnen, Christopher Dirk Keene, Robert F. Hevner, and Thomas J. Montine -- Molecular diagnosis of human disease / Eli S. Williams and Lawrence M. Silverman -- Molecular assessment of human diseases in the clinical laboratory / Sohpie J. Deharvengt and Gregory J. Tsongalis -- Pharmacogenomics and personalized medicine in the treatment of human diseases / Robert D. Nerenz.

As the molecular basis of human disease becomes better characterized, and the implications for understanding the molecular basis of disease becomes realized through improved diagnostics and treatment, Molecular Pathology, Second Edition stands out as the most comprehensive textbook where molecular mechanisms represent the focus. It is uniquely concerned with the molecular basis of major human diseases and disease processes, presented in the context of traditional pathology, with implications for translational molecular medicine. The Second Edition of Molecular Pathology has been thoroughly updated to reflect seven years of exponential changes in the fields of genetics, molecular, and cell biology which molecular pathology translates in the practice of molecular medicine. The textbook is intended to serve as a multi-use textbook that would be appropriate as a classroom teaching tool for biomedical graduate students, medical students, allied health students, and others (such as advanced undergraduates). Further, this textbook will be valuable for pathology residents and other postdoctoral fellows that desire to advance their understanding of molecular mechanisms of disease beyond what they learned in medical/graduate school. In addition, this textbook is useful as a reference book for practicing basic scientists and physician scientists that perform disease-related basic science and translational research, who require a ready information resource on the molecular basis of various human diseases and disease states. Explores the principles and practice of molecular pathology: molecular pathogenesis, molecular mechanisms of disease, and how the molecular pathogenesis of disease parallels the evolution of the disease. Explains the practice of "molecular medicine" and the translational aspects of molecular pathology Teaches from the perspective of "integrative systems biology."

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