Research methods in occupational epidemiology / Harvey Checkoway, Neil Pearce, Douglas J. Crawford-Brown.

Includes bibliographical references and index.

Print version record.

Occupational epidemiology has emerged as a distinct subdiscipline of epidemiology and occupational medicine, addressing fundamental public health and scientific questions relating to the specification of exposure-response relationships, assessment of the adequacy of occupational exposure guidelines, and extrapolation of hazardous effects to other settings.; This book reviews the wide range of principles and methods used in epidemiological studies of working populations. It describes the historical development of occupational epidemiology, the approaches to characterizing workplace exposures, and the methods for designing and implementing epidemiological studies. The relative strengths and limitations of different study designs are emphasized. Also included are more advanced discussions of statistical analysis, the estimation of doses to biological targets, and applications of the data derived from occupational epidemiology studies to disease modelling and risk assessment. The volume will serve both as a textbook in epidemiology and occupational medicine courses and as a practical handbook for the design, implementation, and interpretation of research.

Historical Background -- The Scope of Occupational Epidemiology -- Characterizing the Workplace Environment -- General Concepts of Exposure and Dose -- Approaches to Exposure Assessment -- Reliability and Validity of Exposure Assessment -- Combining Exposure Data from Multiple Sources -- Overview of Study Designs -- Case Series -- Cohort Studies -- Case-Control Studies -- Proportionate Mortality Studies -- Cross-sectional Studies -- Connections between Study Designs -- Precision and Validity in Study Design -- Precision -- Validity -- Effect Modification and Estimation of Joint Effects -- Cohort Studies -- Basic Cohort Design -- Methods of Data Analysis -- Strategies of Analysis -- Planning a Cohort Study -- Case-Control Studies -- Basic Study Design -- Selection of Cases -- Selection of Controls -- Exposure Data -- Data Analysis -- Cross-sectional and Repeated Measures Studies -- Study Design Features -- Sources of Health and Exposure Data -- Subject Selection Options -- Methods of Data Analysis -- Sources of Bias in Cross-sectional Studies -- Planning Cross-sectional and Repeated Measures Studies -- Occupational Health Surveillance -- Defining Surveillance -- Selecting Health Outcomes for Surveillance -- Surveillance Study Designs -- Surveillance in Defined Occupational Cohorts -- Surveillance in the General Population -- Advanced Statistical Analysis -- Continuous Outcome Data -- Dichotomous Outcome Data -- Model Specification -- Exposure and Dose Modeling -- The Starting Point: The Exposure Profile.

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