Virtual ADMET Assessment in Target Selection and Maturation.
Material type:![Text](/opac-tmpl/lib/famfamfam/BK.png)
- text
- computer
- online resource
- 9781433701559
- 1433701553
- 9781429467728
- 142946772X
- 9781607502197
- 1607502194
- Drug development -- Data processing -- Congresses
- Drug development -- Congresses
- Drugs
- Pharmacokinetics
- Drugs -- Design
- Pharmaceutical Preparations
- Pharmacokinetics
- Drug Design
- Computational Biology
- Médicaments -- Développement -- Informatique -- Congrès
- Médicaments -- Développement -- Congrès
- Médicaments
- Pharmacocinétique
- Médicaments -- Conception
- Bio-informatique
- MEDICAL -- Drug Guides
- MEDICAL -- Pharmacology
- MEDICAL -- Pharmacy
- MEDICAL -- Nursing -- Pharmacology
- Drug development
- 615/.190285
- RM301.25 .V575 2006eb
- 2008 G-399
- QV 744
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OPJGU Sonepat- Campus | E-Books EBSCO | Available |
Preface; List of Contributors; Contents; Conference Preface; The Risky Business of Developing Drugs; Benefits and Limits of in Silico Predictions; Musings on ADME Predictions and Molecular Structure; Lipophilicity: Its Calculation and Application in ADMET Predictions; Interpretation of the Role of the Electrotopological State and Molecular Connectivity Indices in the Prediction of Physical Properties and ADME-Tox Behavior -- Case Study: Human Plasma Protein Binding; Molecular Descriptors for Predicting ADMET Properties; Molecular Fields to Assess Recognition Forces and Property Spaces.
Extracting Pharmacophores from Bio-Active MoleculesIn Silico Models for Human Bioavailability; In Silico Models to Predict Brain Uptake; Algorithms to Predict Affinity for Transporters; Predicting Affinity for and Metabolism by Cytochromes P450; Expert Systems to Predict Biotransformation; Expert Systems to Predict Toxicity; From in Vivo to in Vitro/in Silico ADME: Progress and Challenges; Author Index.
Today, biologists and medicinal chemists realize that there is a strong relationship between pharmacodynamic (what the drug does to the organism) and pharmacokinetic (what the organism does to the drug) effects. A significant contributing factor to the evolution in drug discovery was the methodological and technological revolution with the advent of combinatorial chemistry, high-throughput screening and profiling, and in silico prediction of target-based activity and ADMET (absorption, distribution, metabolism, excretion and toxicity) properties. High-throughput screening and in silico methods.
Print version record.
Includes bibliographical references and index.
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