Hepatobiliary Transport in Health and Disease.

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Preface; List of Contributors; Abbreviations; 1 Physiology of bile formation: Hepatocellular bile salt transporters; 1.1 Introduction; 1.2 Sodium-dependent bile salt uptake into hepatocytes; 1.3 Sodium-independent bile salt uptake into hepatocytes; 1.4 Bile salt export across the canalicular membrane; 1.5 Bile salt salvage systems; 1.6 Concluding remarks; 1.7 References; 2 Structure and function of hepatic ABC transporters; 2.1 Introduction to human ABC transporters expressed in the liver; 2.2 Structure and function of the bile salt export pump (ABCB11; BSEP).

2.3 Structure and function of the multidrug resistance protein 3 (ABCB4 MDR3); 2.4 Structure and function of the breast cancer resistance protein (ABCG2; BCRP); 2.5 Concluding remarks; 2.6 References; 3 Short- and long-term regulation of hepatobiliary transport; 3.1 Introduction; 3.2 Short-term regulation of sinusoidal transport systems; 3.3 Long-term regulation of sinusoidal transport systems; 3.4 Short-term regulation of canalicular secretion; 3.5 Long-term regulation of canalicular transport systems; 3.6 Methods of studying subcellular transporter distribution; 3.7 Summary; 3.8 References.

4 Nuclear bile acid receptor FXR and hepatobiliary transport systems4.1 Introduction; 4.2 Nuclear receptors; 4.3 Bile acids and the enterohepatic circulation; 4.4 Bile acid homeostasis, enterohepatic circulation, and FXR; 4.5 The role of FXR in the pathogenesis of biliary diseases; 4.6 Concluding remarks; 4.7 References; 5 Bile acid signaling in the liver and the biliary tree; 5.1 Introduction; 5.2 Bile acid signaling in liver parenchymal cells (hepatocytes); 5.3 Bile acid signaling in sinusoidal endothelial cells; 5.4 Bile acid signaling in Kupffer cells.

5.5 Bile acid signaling in hepatic stellate cells5.6 Bile acid signaling in the biliary tree; 5.7 References; 6 Modulation of innate immunity and inflammation by bile acids and their receptors; 6.1 Introduction; 6.2 Impact of FXR deletion on immunity and inflammation -- lessons from FXR knockout mice; 6.3 Role of TGR5 in the modulation of immune function; 6.4 Effects of bile acids on immunological function independently of bile acid receptors; 6.5 Obstructive jaundice and its impact on immune function; 6.6 Role of bile acids and FXR in viral infections; 6.7 Concluding remarks; 6.8 References.

7 Bile acids as extrahepatic and interorgan signaling molecules7.1 Introduction; 7.2 Bile acid-dependent modulation of glucose homeostasis; 7.3 Impact of bile acids on energy expenditure; 7.4 Bile acid receptors and immune response; 7.5 Role of bile acid receptors in the cardiovascular system; 7.6 Role of bile acid receptors in the kidney; 7.7 Bile acid receptors in the central and peripheral nervous system; 7.8 Summary and future perspectives; 7.9 References; 8 Disorders of bile duct development; 8.1 Introduction.

The transport systems involved in hepatobiliary transport have been cloned and characterized at the molecular level and it is becoming clear that mutations and polymorphisms of individual transporter molecules underlie a variety of liver diseases. This book provides surveys on the structure and function of transport molecules involved in hepatobiliary transport, on the role of different bile acids receptors in various organs and their function in health and disease. The book will be of interest for biochemists, structural chemists, biologists and clinicians.

Includes bibliographical references and index.

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