Drug discovery and development for Alzheimer's disease 2000 / Howard M. Fillit, Alan W. O'Connell, editors.

Includes bibliographical references and index.

Print version record.

This prestigious volume presents the findings of an international group of academic and biotechnological researchers. Topics range from early detection programs focusing on genetic factors, novel probes for detecting B-amyloid in the living brain, and the use of telephonic screening and MRI's to the diversity of therapeutic areas such as antioxidants, estrogen agonists and various anti-B-amyloid and anti-tangle approaches. The volume is still an indispensable resource for the psychogeriatrician, psychiatrist, clinical investigator, and neurobiologist, and a must for medical libraries.

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1. The Challenges of Drug Discovery and Drug Development for Cognitive Aging and Alzheimer's Disease / Howard Fillit and Alan O'Connell -- pt. I. Early Detection -- 2. Genetic Correlates of Successful Cognitive Aging / Thomas Perls -- 3. Genetic and Environmental Risk Factors for Alzheimer's Disease in Arabs Residing in Israel / Robert P. Friedland, Amos Korczyn and Lindsay Farrer -- 4. Telephonic Screening of Mental Status: A Feasibility Study in a Managed Care Clinic / David Knopman, Thomas Vonsternberg and Jim Haefemeyer -- 5. Use of Brain MRI Volumetric Analysis in a Mild Cognitive Impairment Trial to Delay the Diagnosis of Alzheimer's Disease / Michael Grundman, Drahomira Sencakova and Clifford R. Jack, Jr. / [and others] -- 6. Hippocampal Volume Assessment in Mild Cognitive Impairment / Michael S. Mega, Paul M. Thompson and Arthur W. Toga / [and others] -- 7. Brain Imaging Surrogate Markers for Detection and Prevention of Cognitive Aging and Alzheimer's Disease / Gary W. Small -- 8. Novel [beta]-Amyloid Probes / Mei-Ping Kung, Zhi-Ping Zhuang and Catherine Hou / [and others] -- 9. Early Clinical and Biological Manifestations of Alzheimer's Disease: Implications for Screening and Treatment / Richard C. Mohs, Deborah Marin and Vahram Haroutunian -- pt. II. Drug Discovery -- 10. Identification of Brain-Expressed ABC Transporters That May Mediate Detachment of [beta]-Amyloid From Biological Membranes / Peter B. Reiner and Stephane Le Bihan -- 11. Targeting an RNA Structure in the Amyloid Precursor Protein Gene as a New Therapeutic Strategy for Alzheimer's Disease / Jack T. Rogers -- 12. Novel Tricyclic Pyrone Compounds Prevent Intracellular APP C99-Induced Cell Death / Lee-Way Jin, Duy H. Hua and Feng-Shiun Shie / [and others] -- 13. Novel Glycosaminoglycans as Antiamyloid Agents / Robert Kisilevsky and Walter A. Szarek -- 14. Strategies for Inhibiting Alzheimer's [gamma]-Secretase / Michael S. Wolfe -- 15. Phosphorylations of Tau and APP as Targets for Drug Discovery / John DeBernardis, Dan Kerkman and Cintia Vianna / [and others] -- 16. Estrogen and ApoE: Drug Discovery Implications / Jonathan D. Smith and Justine A. Levin -- 17. Structure-Based Functional Design of Agonists and Antagonists for AMPA-Subtype Glutamate Receptors / Ming-Ming Zhou, Harel Weinstein and Diomedes E. Logothetis / [and others] -- 18. Alzheimer's Therapeutics: Neurotrophin Small Molecule Mimetics / Stephen M. Massa, You-Mei Xie and Frank M. Longo -- pt. III. Drug Development -- Preclinical -- 19. Antioxidants in the Treatment of Alzheimer's Disease: Breakthrough Potential of Indole-3-Propionic Acid / Daniel G. Chain, Douglas Galasko and Eyal Neria / [and others] -- 20. AF150(S) and AF267B: M1 Muscarinic Agonists for Treatment and as Disease-Modifying Agents in Alzheimer's and Related Diseases / A. Fisher, Z. Pittel and R. Brandeis / [and others] -- 21. ABS-205: Effects on Cognition in Mature and Aged Rats / Ciaran M. Regan -- 22. Calpain Inhibitors: A Treatment of Alzheimer's Disease / Ottavio Arancio -- 23. Femtomolar-Acting Neuroprotective Peptides: Application for Inhibition of Alzheimer's Disease / Illana Gozes, Sharon Furman and Ruth A. Steingart / [and others] -- pt. IV. Drug Development -- Clinical -- 24. A Phase I Clinical Study of Ex Vivo Nerve Growth Factor Gene Therapy for Alzheimer's Disease / Mark H. Tuszynski -- 25. Lowering Homocysteine Levels in Patients With Alzheimer's Disease / Paul Aisen, Mary Sano and Ramon Diaz-Arrastia / [and others] -- 26. Therapeutic Potential of Positive AMPA Receptor Modulators in Mild Cognitive Impairment and Alzheimer's Disease / Steven A. Johnson, Gary Lynch and Gary A. Rogers / [and others] -- 27. The Alzheimer's Disease Atorvastatin Treatment Trial: Scientific Basis and Position on the Use of HMG-CoA Reductase Inhibitors (Statins) That Do or Do Not Cross the Blood-Brain Barrier / D. Larry Sparks, Donald J. Connor and Patrick J. Browne / [and others] -- 28. A Double-Blind, Randomized Investigation of the Effects of Testosterone or Placebo in Male Patients With Mild-to-Moderate Alzheimer's Disease / Bruce Miller -- 29. Estrogen and Cognitive Functioning in Men With Mild Cognitive Impairment / Barbara B. Sherwin and Howard Chertkow.

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