Oncologic Thermoradiotherapy: Need for Evidence, Harmonisation, and Innovation
Material type:![Article](/opac-tmpl/lib/famfamfam/AR.png)
- books978-3-0365-4531-8
- 9783036545325
- 9783036545318
- Medicine
- Oncology
- perfusion estimation
- temperature monitoring
- conductivity reconstruction
- systems medicine
- immune system in silico
- perceptron
- antigen pattern
- danger signal
- fractionation
- immune response
- head and neck cancer
- hyperthermia
- reirradiation
- treatment outcome
- hyperthermia treatment planning
- adaptive planning
- temperature optimization
- low-middle-income group countries
- cancer
- radiotherapy
- chemotherapy
- recurrent breast cancers
- cervical cancer
- head and neck cancers
- cost-effective
- meta-analysis
- intensity-modulated radiotherapy
- prostate cancer
- thermal dose
- thermometric parameters
- preclinical data
- clinical evidence
- modulated electro-hyperthermia
- abscopal effect
- locally advanced cervical cancer
- resource-constrained setting
- radiosensitiser
- rectal cancer
- chemoradiotherapy
- tumour control
- loco-regional hyperthermia
- oncology
- cellular selection
- bioelectromagnetics
- complexity
- immune-effects
- moderate hyperthermia
- deep hyperthermia
- radiative hyperthermia
- patterns of care
- reimbursement
- regional hyperthermia
- neoadjuvant chemoradiation
- survival
- induced
- brachytherapy
- prostatic neoplasms
- interstitial hyperthermia
- treatment plan optimization
- prostate
- thermoradiotherapy
- linear quadratic model
- biological modeling
- thermal dosimetry
- hypoxia
- radiation therapy
- reoxygenation
- perfusion
- oxygen consumption rate
- local tumor control
- biomarker
- immune phenotype
- hyperthermia treatment sequence
- breast cancer
- immune checkpoint molecules
- dendritic cell activation
- n/a
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Open Access star Unrestricted online access
The road of acceptance of oncologic thermotherapy/hyperthermia as a synergistic modality in combination with standard oncologic therapies is still bumpy. This is partially due to the lack of level I evidence from international, multicentric, randomized clinical trials including large patient numbers and a long term follow-up. Therefore we need more level I EVIDENCE from clinical trials, we need HARMONISATION and global acceptance for existing technologies and a common language understood by all stakeholders and we need INNOVATION in the fields of biology, clinics and technology to move thermotherapy/hyperthermia forward. This is the main focus of this reprint. In this reprintyou find carefully selected and peer-reviewed contributions from Africa, America, Asia, and Europe. The published papers from leading scientists from all over the world covering a broad range of timely research topics might also help to strengthen thermotherapy on a global level.
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