Cellular signaling and innate immune responses to RNA virus infections / edited by Allan R. Brasier, Adolfo García-Sastre, Stanley M. Lemon.

Includes bibliographical references and index.

Role of toll-like receptors in the innate immune response to RNA viruses / Sinéad E. Keating and Andrew G. Bowie -- Cytoplasmic pattern receptors and signaling in viral infections / Osamu Takeuchi and Shizuo Akira -- Mitochondrial antiviral signaling / Vijay G. Bhoj and Zhijian J. Chen -- Interferon regulatory factors and the atypical IKK-related kinases TBK1 and IKK? : essential players in the innate immune response to RNA virus infection / Meztli Arguello, Suzanne Paz, and John Hiscott -- Jak-stat pathway in response to virus infection / Joan E. Durbin -- Interferons and antiviral action / Christine L. White and Ganes C. Sen -- The nuclear factor-kB transcription factor pathway / Amer A. Beg and Xingyu Wang -- The nuclear factor-kB signaling network : insights from systems approaches / Allan R. Brasier -- Type 1 interferon signaling in shaping cellular innate and adaptive immunity to viral infection / Christine A. Biron -- Biological impact of type I interferon induction pathways beyond their antivirus activity / Bahram Razani [and others] -- Human genetic factors involved in viral pathogenesis / Lennart Svensson and Elin Kindberg -- RNA virus families : distinguishing characteristics, differences, and similarities / Peter W. Mason and Frank Scholle.

Rhabdoviruses and mechanisms of type I interferon antagonism / Krzysztof Brzózka and Karl-Klaus Conzelmann -- Filoviruses / Christopher F. Basler -- Inhibition of antiviral signaling pathways by paramyxovirus proteins / Antonella Casola [and others] -- Suppression of innate immunity by orthomyxoviruses / Randy A. Albrecht and Adolfo García-Sastre -- Bunyaviruses and innate immunity / Friedemann Weber and Richard M. Elliott -- Arenaviruses / Juan C. de la Torre -- Regulation of innate immunity by the flaviviridae / Brenda L. Fredericksen and Michael Gale Jr. -- Evasion of innate host antiviral defenses by picornaviruses / Stanley M. Lemon -- Togaviruses / William B. Klimstra and Kate D. Ryman -- Coronaviruses and arteriviruses / Krishna Narayanan and Shinji Makino -- Caliciviridae and astroviridae / Susana Guix and Mary K. Estes -- Innate immune responses elicited by reovirus and rotavirus / Barbara Sherry, John T. Patton, and Terence S. Dermody -- Summary and perspectives / Allan R. Brasier, Adolfo García-Sastre, and Stanley M. Lemon.

Print version record.

Divided into two major sections, this volume synthesizes recent findings in this fast-moving field while also reviewing accepted knowledge. The first part focuses on the antiviral signaling pathways in the host, including specific pattern recognition receptors (PRRs) and how these cellular alarms signal the innate immune response. The second section examines the ways in which specific major RNA virus families interact with, activate, and elude these signaling pathways and responses.

English.

eBooks on EBSCOhost EBSCO eBook Subscription Academic Collection - Worldwide