The EGF receptor family : biologic mechanisms and role in cancer / edited by Graham Carpenter.

The enormity of the literature on growth factors, plus the breadth of the biological disciplines and technical expertise required prohibits a comprehensive review by even a multi-disciplinary panel of authors. To provide an alternative that is feasible for authors and digestible by readers, this review compendium consists of a collection of articles, each covering an aspect of the ErbB/EGF field. This compilation features articles on growth factor ligands, neuregulins, and individual receptors. The second part of the book concentrates on the biological context of the ErbB receptors, particularly in mammary development and in cancer. It concludes with a discussion of the genetic systems that have enabled significant advances in research in this area.

Includes bibliographical references.

Cover -- Contents -- Introduction -- Raymond C. Harris, Eunkyung Chung, and Robert J. Coffey -- EGF receptor ligands -- Douglas L. Falls -- Neuregulins: functions, forms, and signaling strategies -- Robert N. Jorissen, Francesca Walker, Normand Pouliot, Thomas P.J. Garrett, Colin W. Ward, and Antony W. Burgess -- Ami Citri, Kochupurakkal Bose Skaria, and Yosef Yarden -- The deaf and the dumb: the biology of ErbB-2 and ErbB-3 -- Graham Carpenter -- ErbB-4: mechanism of action and biology -- H. Steven Wiley -- Trafficking of the ErbB receptors and its influence on signaling -- David F. Stern -- ErbBs in mammary development -- Thomas Holbro, Gianluca Civenni, and Nancy E. Hynes -- The ErbB receptors and their role in cancer progression -- Julie L. Boerner, Andrew Danielsen, and Nita J. Maihle -- Ligand-independent oncogenic signaling by the epidermal -- Carlos L. Arteaga -- ErbB-targeted therapeutic approaches in human cancer -- David W. Fry -- Mechanism of action of erbB tyrosine kinase inhibitors -- Ben-Zion Shilo -- Signaling by the Drosophila epidermal growth factor receptor pathway during development -- Nadeem Moghal and Paul W. Sternberg -- The epidermal growth factor system in Caenorhabditis elegans -- Last Page.

Print version record.

English.

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