Testosterone and aging : clinical research directions / Committee on Assessing the Need for Clinical Trials of Testosterone Replacement Therapy, Board on Health Sciences Policy ; Catharyn T. Liverman and Dan G. Blazer, editors.

Includes bibliographical references.

INTRODUCTION -- Scope of this Report -- Aging and Hormonal Changes -- Testosterone, Human Development, and Health -- Measuring Testosterone Levels -- Testosterone Therapy -- Growing Use of Testosterone Therapy -- Clinical Trials -- TESTOSTERONE AND HEALTH OUTCOMES -- Changes in Endogenous Testosterone Levels with Aging -- Literature Review -- Bone -- Body Composition and Strength -- Physical Function -- Cognitive Function -- Mood and Depression -- Sexual Function -- Health-Related Quality of Life -- Cardiovascular and Hematologic Outcomes -- Prostate Outcomes -- Other Health Outcomes -- Multiple Outcomes -- FUTURE RESEARCH DIRECTIONS -- Strategy for Future Clinical Trials in Older Men -- Recommendations -- Initial Efficacy Trials in Older Men -- Protection of Research Participants: Safety and Ethical Issues -- Additional Areas of Research -- Need for Efficacy Studies in Older Men -- Clinical Studies in Middle-Aged Men.

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