Integrative approaches to molecular biology / edited by Julio Collado-Vides, Boris Magasanik, and Temple F. Smith.

Consequence of a meeting held at the Center for Nitrogen Fixation, National Autonomous University of Mexico, Cuernavaca, in Feb. 1994.

Includes bibliographical references (pages 303-330) and index.

Print version record.

Evolution as engineering / Richard C. Lewontin -- Analysis of bacteriophage T4 based on the completed DNA sequence / Elizabeth Kutter -- The identification of protein functional patterns / Temple F. Smith, Richard Lathrop, and Fred E. Cohen -- Comparative genomics : a new integrative biology / Robert J. Robbins -- On genomes and cosmologies / Antoine Danchin -- A kinetic formalism for integrative molecular biology : manifestation in biochemical systems theory and use in elucidating design principles for gene circuits / Michael A. Savageau -- Genome analysis and global regulation in Escherichia coli / Frederick C. Neidhardt -- Feedback loops : the wheels of regulatory networks / René Thomas -- Integrative representations of the regulation of gene expression / Julio Collado-Vides -- Eukaryotic transcription / Thomas Oehler and Leonard Guarente -- Analysis of complex metabolic pathways / Michael L. Mavrovouniotis -- Where do biochemical pathways lead? / Jack Cohen and Sean H. Rice -- Gene circuits and their uses / John Reinitz and David H. Sharp -- Fallback positions and fossils in gene regulation / Boris Magasanik -- The language of the genes / Robert C. Berwick.

What are the main challenges of computational molecular biology once the genome projects are completed? Integrative Approaches to Molecular Biology focuses on molecular biology beyond sequences: from gene regulation to differentiation, a higher-level integration that will be a major theme in biology following conclusion of the genome program. It charts the course of the emerging discipline of integrative molecular biology from macromolecular sequences to a biological (and theoretical) perspective, showing that novel integrative methodologies and paradigms are emerging at the confluence of such disciplines as computer science, logic, linguistics, and mathematics. Following an introductory chapter by Richard Lewontin that offers a critique of the evolutionary process as one of engineering design, the first part of the book, on computational biology, addresses issues concerning protein and DNA sequences within genome projects and a federated infrastructure for databases. The second part brings together experimental, evolutionary, computational, and theoretical approaches dealing with regulation of gene expression, metabolic pathways, and cell differentiation. The book concludes with a chapter on problems and perspectives on artificial intelligence.

English.

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