Network medicine : complex systems in human disease and therapeutics / edited by Joseph Loscalzo, Albert-László Barabási, Edwin K. Silverman.

Contributor(s):

Material type: Text

TextPublisher: Cambridge, Massachusetts : Harvard University Press, 2017Description: 1 online resource (xi, 436 pages) : illustrations (chiefly color)Content type:

text

Media type:

computer

Carrier type:

online resource

ISBN:

9780674545533
0674545532

Subject(s):

Genre/Form:

Electronic books.

Additional physical formats: Print version:: Network medicine.DDC classification:

610.285 23

LOC classification:

R858 .N48 2017eb

NLM classification:

2017 C-319
QU 26.5

Online resources:

Click here to access online

Contents:

Scientific basis of network medicine / Edwin K. Silverman and Joseph Loscalzo -- Introduction to network analysis / Jorg Menche and Albert-Laszlo Barabasi -- Human interactomes in network medicine / Michael E. Cusick, Benoit Charloteaux, Thomas Rolland, Michael A. Calderwood, David E. Hill, and Marc Vidal -- Social networks in human disease / Martin W. Schoen and Douglas Luke -- Phenotype, pathophenotype and endo(patho)phenotype in network medicine / Calum A. MacRae -- A new paradigm for defining human disease and therapy / Joseph Loscalzo -- Complex disease genetics and network medicine / Edwin K. Silverman -- Transcriptomics and network medicine / Kimberly Glass and John Quackenbush -- Post-translational modifications of the proteome: the example of Tau in the neuron and the brain / Guy Lippens, Jeremy Gunawardena, Isabelle Landrieu, Caroline Smet-Nocca, Sudhakaran Prabakaran, Benjamin Parent, Arnaud Leroy, and I. Huvent -- Epigenetics and network medicine / Dawn L. DeMeo and Scott T. Weiss -- Metabolomics and network medicine / Jessica Lasky-Su and Clary B. Clish -- Using integrative Omics approaches in network medicine / Shuyi Ma, John C. Earls, James A. Eddy, and Nathan D. Price -- Cancer network medicine / Takeshi Hase, Samik Ghosh, Sucheendra K Palaniappan, and Hiroaki Kitano -- Systems pharmacology in network medicine / Edwin K. Silverman and Joseph Loscalzo -- Systems approaches to clinical trials / Elliott M. Antman -- Microbiomics in network medicine / Joanne E. Sordillo, George M. Weinstock, and Augusto A. Litonjua.

Summary: "Network medicine, a new field which developed from the application of systems biology approaches to human disease, embraces the complexity of multifactorial influences on disease, which can be driven by non-linear effects and molecular and statistical interactions. The development of comprehensive and affordable Omics platforms provides the data types for network medicine, and graph theory and statistical physics provide the theoretical framework to analyze networks. While network medicine provides a fundamentally different approach to understanding disease etiology, it will also lead to key differences in how diseases are treated--with multiple molecular targets that may require manipulation in a coordinated, dynamic fashion. Much remains to be learned regarding the optimal approaches to integrate different Omics data types and to perform network analyses; this book provides an overview of the progress that has been made and the challenges that remain."-- Provided by publisher

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Holdings
Item type	Home library	Collection	Call number	Materials specified	Status	Date due	Barcode
Electronic-Books	OPJGU Sonepat- Campus	E-Books EBSCO			Available

"Network medicine, a new field which developed from the application of systems biology approaches to human disease, embraces the complexity of multifactorial influences on disease, which can be driven by non-linear effects and molecular and statistical interactions. The development of comprehensive and affordable Omics platforms provides the data types for network medicine, and graph theory and statistical physics provide the theoretical framework to analyze networks. While network medicine provides a fundamentally different approach to understanding disease etiology, it will also lead to key differences in how diseases are treated--with multiple molecular targets that may require manipulation in a coordinated, dynamic fashion. Much remains to be learned regarding the optimal approaches to integrate different Omics data types and to perform network analyses; this book provides an overview of the progress that has been made and the challenges that remain."-- Provided by publisher