Science, technology and application of folic acid encapsulation / Honest Sindile Madziva and Kasipathy Kailasapathy.

Includes bibliographical references and index.

Description based on print version record and CIP data provided by publisher.

Intro; Contents; Preface; Acknowledgements; About the Authors; List of Abbreviations; Chapter 1; Introduction; 1.1. Aim; 1.2. Objectives; Chapter 2; Literature Review; 2.1. Discovery and Chemistry of Folates; 2.2. The Role of Folic Acid in Health and Disease; 2.3. Neural Tube Defects (NTDs); 2.4. Occlusive Vascular Disease Associated with Elevated Homocysteine; 2.4.1. Cancer; 2.4.2. Cognitive Function; 2.4.3. Osteoporosis; 2.5. Strategies to Increase Blood Folate Levels; 2.6. Intestinal Absorption of Folates; 2.7. Stability of Folates; 2.8. Strategies to Raise Folate Levels in Food Products

2.8.1. Plant Gene Manipulation2.8.2. Bio-Fermentation; 2.8.3. Metabolic Engineering; 2.8.4. Multi-Faceted Approach; 2.9. Cheese as a Food Vehicle; 2.10. Regulatory Requirements for Cheddar Cheese Fortification; 2.11. Microencapsulation; 2.11.1. Definition; 2.11.2. Controlled Release; 2.12. Encapsulating Materials; 2.12.1. Alginate; 2.12.1.1. Type, Form and Concentration of Divalent Cation Vector; 2.12.2. Pectin; 2.13. Microencapsulation Techniques; 2.13.1. Spray-Drying; 2.13.2. Spray-Chilling or Spray-Cooling; 2.13.3. Fluidized-Bed Coating; 2.13.4. Extrusion; 2.13.5. Centrifugal Extrusion

2.13.6. Lyophilization2.13.7. Coacervation; 2.13.8. Centrifugal Suspension Separation; 2.13.9. Co-Crystallization; 2.13.10. Liposome Entrapment; 2.13.11. Inclusion Complexation; 2.14. Summary and Recent Literature; 2.14.1. Folic Acid, Deficiency, Bioactivity, Structure and Stability; 2.14.2. Microencapsulation of Folic Acid; 2.15. Future Trends; Chapter 3; Materials and Methods; 3.1. Folic Acid Encapsulation Procedure; 3.2. Effect of Time and Calcium Chloride Concentration on Cross-Linking Completion in Alginate-Pectin Hydrogels

3.3. Effect of Buffer Type on Folic Acid Release from Alginate-Pectin Hydrogels3.4. Single and Blended Polymer Effect on Folic Acid Encapsulation Efficiency; 3.5. Effect of Different Drying Techniques on Retention of Encapsulated Folic Acid; 3.6. Folic Acid Leakage; 3.7. Morphology of Gel Capsules; 3.8. Folic Acid Measurement Using the TECRA® Quantitative Folate Assay (QFA) Kit; 3.8.1. Principle of the Test; 3.8.2. Reagent Preparation; 3.8.3. Sample Preparation; 3.8.4. Performing the Assay; 3.9. Effect of Simulated Cheese Press Pressures on Mechanical Stability of Capsules

3.10. Cheddar Cheese Making3.12. Total Folates Measurement; 3.13. Statistical Analyses; Chapter 4; Screening of Food Grade Polymers and Optimisation of Folic Acid Encapsulation Parameters to Increase Encapsulation Efficiency and Stability; Abstract; 4.1. Introduction; 4.2. Aim; 4.3. Objectives; 4.4. Preparation of Polymer Solutions and Encapsulation Procedure; 4.5. Optimisation of Encapsulation Parameters; 4.6. Selection of Buffer for the Release of Folic Acid; 4.7. Effect of Different Drying Methods on Stability of Encapsulated Folic Acid

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