Aminoglycosides : pharmacology, clinical uses and health effects / Ruthie Alves, editor.

Includes bibliographical references (pages [97]-102) and index.

Description based on print version record and CIP data provided by publisher.

Preface; Chapter 1; Amphiphilic Analogues of Aminoglycosides as Antitubercular and Antimicrobial Agents; Abstract; 1. Introduction; 1.1. Background; 1.2. Drug Resistant Tuberculosis; 1.3. Tuberculosis Chemotherapy; 1.4. The DOTS Treatment Regimen; 1.5. Aminoglycosides; 1.6. Aminoglycoside Structure; 1.7. Bacterial Uptake of Aminoglycosides; 1.8. Molecular Mechanism of Action; 1.9. Mechanisms of Resistance; (i) Reduction of the Intracellular Drug Concentration -- A Result of Reduced Permeability or Action of Efflux Pumps; (ii) Spontaneous Mutation of the Ribosomal Target.

(Iii) Modification of the Antibiotic by Aminoglycoside Modifying Enzymes (AMEs)2. Amphiphilic Aminoglycosides; 2.1. Neomycin; 2.2. Tobramycin; 2.3. Neamine; 2.4. Paromomycin; 2.5. Kanamycin; 2.6. Amikacin; 2.7. Netilmicin and Sisomicin; 2.8. Nebramine; 2.9. Arbekacin; Conclusion; References; Chapter 2; Aminoglycoside Use in Patients with Chronic Kidney Disease; Abstract; Introduction; Pharmacology; Pharmacokinetics; Mechanism of Action; Aminoglycoside Toxicity; Post-Antibiotic Effect; Adaptive Resistance; Key Points; Dosing, Monitoring and Clearance in Chronic Kidney Disease.

Dosing and FormulaeMonitoring Aminoglycoside Levels; Inhaled Aminoglycosides; Key Points; Dosing, Monitoring and Clearance in Haemodialysis; Intermittent Haemodialysis; Continuous and Extended Dialysis Modalities; Aminoglycoside Catheter Locks; Key Points; Dosing, Monitoring and Clearance in Peritoneal Dialysis; Intraperitoneal Antibiotics; Topical Aminoglycosides for Exit Sites; Key Points; Conclusion; References; Chapter 3; Partial or Complete Vestibular Recovery Is Related to the Presence of mitDNA Specific Polymorphisms in Aminoglycoside Antibiotic Treated Female Patients.

1Division of Neurosciences and Molecular Biology Unit, Institute of Cellular Physiology, National Autonomous University of Mexico, Mexico City, Mexico2Audiology and Otoneurology Service, Hospital Angeles de las Lomas, Mexico, DF, Mexico; 3Building A-6, Department 102, Torres de Mixcoac, ; México, D.F. México; Abstract; Introduction; Material and Methodology; Results; Discussion; Conclusion; Acknowledgments; References; Commentary; Gentamicin-Induced Nephrotoxicity: Sesame Oil as a Potential; Protective Agent; References; Related Nova Publications.

Use of Natural Products to Enhance the Antibiotic Activity of Gentamicin and Other Aminoglycosides: The Future of Antibiotictherapy*2Department of Biological Chemistry, Regional University of Cariri, Crato, CE, Brazi; Bibliography; Index.

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