Exosomes : biogenesis, therapeutic applications and emerging research / Armando Meyer, editor.

Includes bibliographical references and index.

Description based on print version record and CIP data provided by publisher.

Preface; Chapter 1; Molecular Mechanisms of Exosome Biogenesis; Abstract; Introduction; 1. Origin of Exosomes; 2. Exosome Biogenesis: Membrane Bending and Cargo Recruitment; The ESCRT Machinery; ESCRT-Dependent Mechanisms of Exosome Biogenesis; ESCRT-Independent Mechanisms of Exosome Biogenesis; Ceramide; Lysobisphosphatidic Acid (LBPA); Tetraspanins; 3. Exosome Release; Is Exosome Release Signal Dependent?; Rab GTPases Regulate Exosomes Release; The Role of Cytoskeleton and SNAREs in Exosome Release; 4. The Diversity of MVBs; Conclusion; References; Chapter 2.

Phenotyping of Small Extracellular Vesicles from Clinically Important Body Fluids Using Protein MicroarrayAbstract; Introduction; Material and Methods; Sampling; Printing of Protein Microarrays; EV Array Analysis; Data Analysis; Results and Discussion; Acknowledgments; References; Chapter 3; Exosomes: Mediators of Cell-Cell Communication and Potential Biomarkers in Cancer; Abstract; Introduction; 1. Exosome Biogenesis; 2. Exosomes in Cancer; 2.1. Oncogenic Transformation and Tumor Formation; 2.2. Angiogenesis; 2.3. Niche Formation and Metastasis; 2.4. Immune Evasion.

2.5. Chemotherapy Evasion3. Therapeutic Use; 4. Exosomes as Biomarkers; Conclusion; References; Chapter 4; Extracellular Vesicles in the Reproductive Tracts: Roles in Sperm Maturation and Function; Abstract; Introduction; Extracellular Vesicles, Characterization, Biogenesis and Impact; Conclusion; Acknowledgments; References; Index.

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