Wound healing : cellular mechanisms, alternative therapies and clinical outcomes / Lacie E. Wade, editor.

Includes index.

WOUND HEALING: CELLULAR MECHANISMS, ALTERNATIVE THERAPIES AND CLINICAL OUTCOMES; WOUND HEALING: CELLULAR MECHANISMS, ALTERNATIVE THERAPIES AND CLINICAL OUTCOMES; Library of Congress Cataloging-in-Publication Data; Contents; Preface; Chapter 1: The Use of Negative Pressure Wound Therapy in Children: An Updated Review; Abstract; Abbreviations; 1. Introduction; 2. Wound Healing and Negative Pressure Wound Therapy; 3. Negative Pressure Wound Therapy Research; 3.1. Animal Models of Negative Pressure Wound Therapy; 3.2. Advantages and Limitations of the Experimental Model.

4. Review of Literature on Negative Pressure Wound Therapy in Children4.1. Overview; 4.2. Types and Sizes of Negative Pressure Dressings Used; 4.3. Pressure Settings; 4.4. Duration of Therapy; 4.5. Location of Wounds; 4.6. NPWT in Conjunction with Supplemental Dressings; 4.7. NPWT in Conjunction with Skin Grafts and Free-Flaps; 4.8. NPWT Following Cardiac Surgery; 4.9. NPWT and the Treatment of Necrotizing Fasciitis Wounds; 4.10. NPWT and the Open Abdomen; 5. Innovation in Negative Pressure Wound Therapy; 6. Caution, Critical Remarks, and Recommendations; Future Development of Interest.

DisclosuresAbout the Authors; References; Chapter 2: Reduction of Profibrotic Connective Tissue Growth Factor in Wounded Rat Corneas Using a Ribozyme Expressed in Self Complimentary Adeno-Associated Virus; Abstract; Introduction; Methods; Production of Secreted Alkaline Phosphatase CTGF Target Expression Plasmid; scAAV-CTGF-Active-Rz and scAAV-CTGF-Inactive-Rz Plasmids Construction; Human Embryonic Kidney 293 (HEK293) Cell Culture and Dual Transfection; In Vivo Analysis of scAAV-GFP Delivery in Rabbit Corneas after Ablation; Direct Fluorescence Microscopy; Image Analysis.

In Vivo Analysis of scAAV-CTGF-Active-Rz in Rat Corneas after AblationCTGF Protein Concentration (ELISA); Results; In Vitro Analysis of sc-AAV-CTGF-Rz Plasmid; Delivery of scAAV-GFP to Rabbit Corneas; Delivery of scAAV-CTGF-Active-Rz to Rat Corneas after Ablation; Discussion; Acknowledgments; References; Chapter 3: Honey and Wound Healing: New Solutions from an Old Remedy; 1University of Piemonte Orientale, DiSIT -- Dipartimento di Scienze e Innovazione Tecnologica, viale Teresa Michel, 11, Alessandria, Italy; 2University of Napoli "Federico II", Dipartimento di Farmacia, ; Napoli, Italy.

AbstractHoney's Composition; Antibacterial Properties of Honey; Wound Healing Properties of Honey; Anti-Inflammatory Properties of Honey; Adverse Effects of Honey; Conclusion; References; Chapter 4: Biomaterials for Wound-Healing Applications; Introduction; Polymeric Biomaterials in Wound Healing; Chitin and Chitosan; Collagen/Gelatin; Alginate; Silk Proteins; Fibroin; Sericin; Conclusion; References; Chapter 5: Implications of Involvement of NSAID-Activated Gene 1 in Ulceration and Wound Healing: Lessons from the Oncological and Cardiovascular Studies; Abstract; 1. Introduction.

Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most widely used drugs for the suppression of inflammation and pain. However, the therapeutic uses of NSAIDs are frequently limited by the significant negative side effects including ulceration, most notably in the gastrointestinal tract. This book examines alternative therapies to healing wounds such as negative pressure wound therapy; and the use of honey and biomaterials. The book also examines the implications of involvement of NSAID-activated gene 1 in ulceration and wound healing.

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