New chemistry and new opportunities from the expanding protein universe : proceedings of the 23rd International Solvay Conference on Chemistry, Hotel Métropole, Brussels 16-19 October 2013 / editor, Kurt Wüthrich, The Scripps Research Institute, USA & ETH Zürich, Switzerl [and 4 others].

Includes bibliographical references and index.

Print version record.

I. The International Solvay Institutes; II. Solvay Scientific Committee for Chemistry; III. Acknowledgements; IV. Participants; V. Auditors; VI. Opening Address by Professor M. Henneaux; VII. Preface by Professor K. Wuthrich; Session 1: New Chemistry in the Expanding Protein Universe; 1.1 Novel Chemistry Still to be Found in Nature; My view of the present state of research on new chemistry in the expanding protein universe; My recent contributions to new chemistry in the expanding protein universe

Outlook to future developments of research in the chemistry of the expanding protein universeReferences; 1.2 Natural Product Biosynthesis in the Genomic Age; My view of the present state of research on new chemistry in the expanding protein universe; My recent research contributions to new chemistry in the expanding protein universe; Outlook to future developments of research on new chemistry int he expanding protein universe; Acknowledgments; References; 1.3 Peptide Dendrimers and Polycyclic Peptides; My view of the present state of research on new chemistry in the expanding protein universe

My recent research contributions to new chemistry in the expanding protein universeOutlook to future developments of research on new chemistry in the expanding protein universe; Acknowledgments; References; 1.4 What can Comparative Genomics Reveal about the Mechanisms of Protein Function Evolution?; My view of new chemistry in the expanding protein universe; Recent research contributions to new protein chemistry; Identifying functionally distinct relatives within a protein domain superfamily

Using structural data to derive phylogenetic trees that reveal the evolution of new functions in superfamiliesTo what extent can function diverge within a protein superfamily; Changes in active site residues can modify the chemistry performed; Convergent evolution of functions in superfamilies; Outlook to future developments; Acknowledgments; References; 1.5 Exploring Chromatin Biology Using Protein Chemistry; My view of the present state of research in protein chemistry; My recent research contributions to protein chemistry; Outlook to future developments of research on protein chemistry

AcknowledgmentsReferences; 1.6 Our Expanding Protein Universe; My view of the present state of research on new chemistry in the expanding protein universe; My recent research contributions to new chemistry in the expanding protein universe; Outlook to future developments of research on new chemistry in the expanding protein universe; Acknowledgment; References; 1.7 The Scientific Impact of Freely Available Chemical Probes; Enabling research efforts on the proteome; Our recent research contributions; Outlook to future developments; Acknowledgments; References; 1.8 Discussions of Session 1

A select group of 40 eminent scientists from all parts of the world met to consider the current state of chemical and biological knowledge on the ever-expanding protein universe, and to discuss emerging opportunities for the foreseeable future. Scientific approaches to discover, characterize, and regulate protein functions were discussed over a range of disciplines, including natural product chemistry, microbiology, enzymology, biochemistry, structural biology, chemical biology, and glycobiology. Some notable highlights included discovery of new enzymatic pathways, innovative carbohydrate chemistry, design of proteins containing unnatural amino acids, structural elucidation of complex supramolecular machines, design and application of small molecule drugs, biologics and biosimilars. This fascinating compendium of scientific presentations and in-depth discussions affords a unique perspective on today's protein chemistry and biology as well as on the challenges for tomorrow.

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