Pathophysiology : laboratory exercises / Pavel Sobotka ; reviewers, Jana Slavíková, Marie Pometlová ; authors, authors, Jan Barcal [and seven others] ; technical collaboration, Miluse Volterová.

Online resource; title from PDF cover (ebrary, viewed July 8, 2014).

Content; 1/ Basic Methods; 1.1 Laboratory animals; 1.1.1 Division of laboratory animals; 1.1.2 The quality of animals ; 1.1.3 Ethics of work with experimental animals; 1.1.4 Some vertebrates used in experiments; 1.1.5 Manipulation with laboratory animals; 1.2 Laboratory protocol (report); 1.3 Anesthesia; 1.3.1 General anesthesia; 1.3.2 Local anesthesia; 1.4 Injection technique; 1.5 Basic surgical instruments and sewing material; 1.6 Surgical technique in laboratory animals; 1.6.1 General principles; 1.6.2 Surgical sutures; 1.6.3 Cannulation of the vessels.

1.6.4 Tracheostomia (Insertion of the tracheal cannula)1.7 Basic evaluation of measured data; 2/ General pathological physiology; 2.1 Skin resistance measurement ; 2.1.1 Changes of skin resistance -- galvanic reaction ; 2.2 Disturbances in thermoregulation -- fever; 3/ Blood; 3.1 Experimental hemolytic anemia; 3.2 Changes of coagulation due to peroral anticoagulants; 3.3 The effect of heparin on fibrin formation ; 3.4 Rumpel -- Leede test; 3.5 Direct test of phagocytosis by neutrophils; 4/ Circulation; 4.1 Examination of functional efficiencies of circulation; 4.2 Harvard step test.

4.3 Letunov's test4.4 Telemetric observation of heart rate ; 4.5 Electrocardiogram (ECG) in pathological states of the heart. ; 4.5.1 Description of ECG curve; 4.5.2 Pathological changes on ECG curve; 4.5.2.1 Arrhythmias; 4.5.2.1.1 Disturbances of cardiac impulse initiation; 4.5.2.1.2 Disorders in impulse conduction; 4.5.2.2 ECG changes in inflammatory heart diseases; 4.5.2.3 ECG changes in ischemic heart disease; 4.5.2.4 ECG changes caused by pharmaceuticals; 4.5.2.5 Electrocardiogram changes in electrolyte disturbances; 4.5.2.6 Changes of the P wave; 4.5.2.7 Electric heart stimulation.

4.6 Experimental disorders of the heart5/ Respiration; 5.1 Examination of pulmonary ventilation; 5.2 Influence of decreased partial pressure of oxygen; 5.3 Voluntary apnea; 6/ Digestion; 6.1 Investigation of saliva properties ; 6.2 Operation of the stomach -- insertion of stomach cannula; 7/ Metabolism and thermoregulation; 7.1 Obesity after stereotaxically performed hypothalamic lesion ; 7.2 Developmental dependence of thermoregulation ; 8/ Excretion; 8.1 Ureterostomia; 9/ Endocrinology; 9.1 Metabolic and circulatory changes in experimental thyroid dysfunction; 9.2 Adrenalectomy in rats.

9.3 Castration in male rats10/ Nervous system; 10.1 Vestibular ataxia in a guinea pig; 10.2 Test of motor ability; 10.3 Recordings of bioelectrical brain activity in man -- electroencephalography; 10.4 EEG recordings -- evoked potentials (EP); 10.5 Recordings of spontaneous end evoked ECoG in experimental animal. Experimental epilepsy.

Anglicky psaný ucební text ""Pathophysiology - Laboratory Exercises"" pro zahranicní studenty Lékarské fakulty v Plzni obsahuje úkoly, které slouží pro praktickou výuku patologické fyziologie. V úvodní cásti text seznamuje studenty se základními metodami manipulace se zvíraty a etikou experimentální práce. Druhá kapitola prináší úkoly zamerené na procvicení obecné patologické fyziologie, další kapitoly se zamerují na krev, krevní obeh, dýchání, trávení, metabolismus a termoregulaci, vylucování, vnitrní sekreci, nervovou soustavu a mikroskopické vyšetrení mozku. Publikace obsahuje názorné ilust.

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