Cellular Responses to Stress.

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Preface ; Abbreviations ; 1 Signal transduction by the c-Jun N-terminal kinase By R.J. Davis; 2 Roles of the AMP-activated/SNFI protein kinase family in the response to cellular stress By D.G. Hardie; 3 Making the connection: coupling of stress-activated ERK/MAPK (extracellular-signal-regulated kinase/mitogen-activated protein kinase) core signalling modules to extracellular stimuli and biological responses By J.M. Kyriakis; 4 Stress-activated MAP kinase (mitogen-activated protein kinase) pathways of budding and fission yeasts By J.B.A. Millar.

5 Protein kinase cascades in intracellular signalling by interleukin-I and tumour necrosis factor By J. Saklatvala, J. Dean and A. Finch6 Regulation of actin dynamics by stress-activated protein kinase 2 (SAPK2)- dependent phosphorylation of heat-shock protein of 27 kDa (Hsp27) By J. Landry and J. Huot; 7 DNA-dependent protein kinase and related proteins By G.C.M. Smith, N. Divecha, N.D. Lakin and S.P. Jackson; 8 Stress-induced activation of the heat-shock response: cell and molecular biology of heat-shock factors By J.J. Cotto and R.I. Morimoto.

9 Transcriptional regulation via redox-sensitive iron-sulphur centres in an oxidative stress response By B. Demple, E. Hidalgo and H. Ding10 Adaptive responses to environmental chemicals by C.R Wolf, G. Smith, A.G Smith, K. Brown and C.J. Henderson; 11 Cellular response to cancer chemopreventive agents: contribution of the antioxidant responsive element to the adaptive response to oxidative and chemical stress by J.D. Hayes, E.M. Ellis, G.E. Neat, D.J Harrison and M.M. Manson; Subject index.

Cellular Responses to Stress brings together a group of scientists who work on different but interrelated aspects of cellular stress responses. The book provides state-of-the-art information on the wide spectrum of ways in which cells can respond to different forms of stress induced by chemicals, oxidants, and DNA-damaging agents. Mechanisms are described that involve altered uptake and efflux of chemical agents, intracellular detoxification, and DNA damage responses. Many of these changes trigger a cascade of reactions mediated by stress-activated signaling pathways, which have the.

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