Recent advances in psoriasis : the role of the immune system / Barbara S. Baker.

Includes bibliographical references and index.

Print version record.

Ch. 1. Aetiology, clinical and histological features of psoriasis. 1.1. Clinical features -- 1.2. Genetics -- 1.3. Environmental factors -- 1.4. Histological features -- ch. 2. Skin immune system in psoriasis. 2.1. Skin immune system (SIS) -- 2.2. T cell subpopulations: normal skin -- 2.3. T cell subpopulations: psoriatic skin -- 2.4. Antigen-presenting cells: normal skin -- 2.5. Antigen-presenting cells: psoriatic skin -- 2.6. Endothelial cells -- 2.7. Neutrophils -- 2.8. Mast cells -- 2.9. Keratinocytes -- ch. 3. Immune cell function in psoriasis. 3.1. T lymphocytes: peripheral blood -- 3.2. T lymphocytes: skin -- 3.3. Antigen-presenting cells -- ch. 4. Psoriasis is a T cell-mediated disease. 4.1. Anti-psoriatic treatments -- 4.2. Anti-CD4 monoclonal antibodies -- 4.3. Lymphocyte-selective toxin (DAB[symbol]IL-2) -- 4.4. SCID mouse models -- 4.5. Bone-marrow transplantation -- 4.6. T cell supernatants promote keratinocyte proliferation -- 4.7. Low CD4[symbol]/HIV infection -- ch. 5. ß haemolytic streptococci and psoriasis. 5.1. Group A streptococci as a trigger for guttate psoriasis -- 5.2. Group A streptococci and CP psoriasis -- 5.3. Induction of psoriatic lesions by streptococci -- 5.4. Streptococcal antigens -- 5.5. Immune response to extracellular streptococcal proteins and superantigens -- 5.6. Immune response to streptococcal cellular proteins -- ch. 6. Immune function of psoriatic keratinocytes. 6.1. Cytokine production -- 6.2. Response to cytokines -- 6.3. Antigen/superantigen presentation -- 6.4. Integrins -- 6.5. Apoptosis -- ch. 7. Current and future immunological approaches to treatment of psoriasis. 7.1. Current treatments -- 7.2. Future treatments -- ch. 8. Model for the immunopathogenesis of psoriasis. 8.1. Outline of proposed model -- 8.2. Antigen trigger: group A streptococci (GAS) -- 8.3. CD4[symbol] T lymphocyte/KC interaction -- 8.4. Role of CD8[symbol] T lymphocytes -- 8.5. Site of altered gene expression -- 8.6. Other antigenic triggers.

This book presents the evidence for the belief that psoriasis is a disease of abnormal keratinocyte proliferation induced by T cells. The latest approaches to investigating the immunopathogenesis of this disease, and a review of previous findings, are presented to give an overall picture of the current knowledge in this field. Each topic is discussed in detail, clearly illustrated and well referenced. The book should prove invaluable to clinical dermatologists, and researchers in the fields of immunology and dermatology who have an interest in skin diseases.

eBooks on EBSCOhost EBSCO eBook Subscription Academic Collection - Worldwide