TY  - BOOK
AU  - Jordan,Bňďicte F.
AU  - Sonveaux,Pierre
TI  - Chapter 13 Targeting Tumor Perfusion and Oxygenation Modulates Hypoxia and Cancer Sensitivity  to Radiotherapy and Systemic Therapies
SN  - 23332
PY  - 2011///
PB  - InTechOpen
KW  - Science: general issues
KW  - bicssc
KW  - Blood
KW  - cancer sensitivity
KW  - Hemodynamics
KW  - hypoxia
KW  - Magnetic resonance imaging
KW  - Neoplasm
KW  - Oxygen
KW  - Perfusion
KW  - Radiation therapy
KW  - radiotherapy
KW  - systematic therapies
KW  - tumor
KW  - Vasodilation
N1  - Open Access
N2  - Hypoxia, a partial pressure of oxygen (pO2) below physiological needs, is a limiting factor affecting the efficiency of radiotherapy. Indeed, the reaction of reactive oxygen species    (ROS, produced by water radiolysis) with DNA is readily reversible unless oxygen stabilizes    the DNA lesion. While normal tissue oxygenation is around 40 mm Hg, both rodent and    human tumors possess regions of tissue oxygenation below 10 mm Hg, at which tumor cells    become increasingly resistant to radiation damage (radiobiological hypoxia) (Gray, 1953).    Because of this so-called "oxygen enhancement effect", the radiation dose required to    achieve the same biologic effect is about three times higher in the absence of oxygen than in    the presence of normal levels of oxygen (Gray et al., 1953; Horsman & van der Kogel, 2009).    Hypoxic tumor cells, which are therefore more resistant to radiotherapy than well    oxygenated ones, remain clonogenic and contribute to the therapeutic outcome of    fractionated radiotherapy (Rojas et al., 1992)
UR  - http://library.oapen.org/handle/20.500.12657/32342
UR  - https://library.oapen.org/bitstream/id/9135c10d-07ae-40a5-955f-9830f0301d1e/612595.pdf
ER  -