TY  - GEN
AU  - Bale,Gemma
AU  - Taylor,Nathan
AU  - Mitra,Subhabrata
AU  - Sudakou,Aleh
AU  - Roever,Isabel de
AU  - Meek,Judith
AU  - Robertson,Nicola
AU  - Tachtsidis,Ilias
TI  - Chapter Near-Infrared Spectroscopy Measured Cerebral Blood Flow from Spontaneous Oxygenation Changes in Neonatal Brain Injury
SN  - 978-3-030-34461-0_1
PY  - 2020///
PB  - Springer Nature
KW  - Neonatal medicine
KW  - bicssc
KW  - Near-infrared spectroscopy; Cerebral blood flow; Neonatal brain injury; Hypoxic-ischaemic encephalopathy; Clinical
N1  - Open Access
N2  - Neonates with hypoxic-ischaemic (HI) brain injury were monitored  using a broadband near-infrared spectroscopy (NIRS) system in the neonatal intensive  care unit. The aim of this work is to use the NIRS cerebral oxygenation data  (HbD = oxygenated-haemoglobin  - deoxygenated-haemoglobin) combined with  arterial saturation (SaO2) from pulse oximetry to calculate cerebral blood flow  (CBF) based on the oxygen swing method, during spontaneous desaturation episodes.  The method is based on Fick's principle and uses HbD as a tracer; when a  sudden change in SaO2 occurs, the change in HbD represents a change in tracer  concentration, and thus it is possible to estimate CBF. CBF was successfully calculated  with broadband NIRS in 11 HIE infants (3 with severe injury) for 70 oxygenation  events on the day of birth. The average CBF was 18.0 ± 12.7 ml 100 g−1 min−1  with a range of 4 ml 100 g−1 min−1 to 60 ml 100 g−1 min−1. For infants with severe  HIE (as determined by magnetic resonance spectroscopy) CBF was significantly  lower (p = 0.038, d = 1.35) than those with moderate HIE on the day of birth
UR  - https://library.oapen.org/bitstream/id/0ff4cb0f-ddf3-4700-ab55-35e1f70f872d/Bookshelf_NBK572925.pdf
UR  - https://library.oapen.org/handle/20.500.12657/56697
ER  -