TY  - GEN
AU  - Rupasinghe,H.P.Vasantha
AU  - Rupasinghe,H.P.Vasantha
TI  - Flavonoids and Their Disease Prevention and Treatment Potential
SN  - books978-3-0365-0001-0
PY  - 2021///
CY  - Basel, Switzerland
PB  - MDPI - Multidisciplinary Digital Publishing Institute
KW  - Humanities
KW  - bicssc
KW  - Social interaction
KW  - luteolin
KW  - apigenin
KW  - bacoside A
KW  - bacopaside I
KW  - vasorelaxation
KW  - isorhamnetin
KW  - flavonoid
KW  - bacterial sepsis
KW  - toll-like receptor 4
KW  - inflammation
KW  - citrus flavonoids
KW  - neohesperidin
KW  - anti-aging activity
KW  - chronological lifespan
KW  - synergistic effect
KW  - clinical trials
KW  - natural products
KW  - hyperalgesia
KW  - allodynia
KW  - analgesia
KW  - hypersensitivity
KW  - cytokines
KW  - NF-kB
KW  - defatted pitaya seed
KW  - extraction
KW  - phenolic content
KW  - flavonoid content
KW  - antioxidant activity
KW  - response surface methodology
KW  - flavonoids
KW  - aglycons
KW  - glycosides
KW  - IL-1β
KW  - TNF-α
KW  - IL-6
KW  - IL-8
KW  - pro-inflammatory cytokines
KW  - Acer okamotoanum
KW  - afzelin
KW  - isoquercitrin
KW  - obesity
KW  - quercitrin
KW  - aspirin
KW  - cancer prevention
KW  - hydroxybenzoic acids
KW  - cell cycle
KW  - CDKs
KW  - colorectal cancer
KW  - infectious diseases
KW  - amoebiasis
KW  - Mexican oregano
KW  - bioguided isolation
KW  - antiprotozoal agents
KW  - flavones
KW  - cancer
KW  - microbiome
KW  - molecular mechanisms
KW  - gene and protein regulatory networks
KW  - macrophages
KW  - NF-κB
KW  - IKKβ, inflammatory cytokines
KW  - apoptosis
KW  - foods for health
KW  - tangeretin
KW  - cancer stem cells
KW  - Stat3
KW  - citrus
KW  - CD44+/CD24−
KW  - phytochemicals
KW  - flavonoids and their derivatives
KW  - phytomedicine
KW  - COVID-19
KW  - SARS-COV-2
KW  - smart nanoparticles
KW  - non-flavonoids
KW  - membrane PUFAs profile
KW  - cell morphology
KW  - human colon cancer cells
KW  - cranberry
KW  - urinary tract infections
KW  - UTIs
KW  - uropathogenic Escherichia coli
KW  - UPEC
KW  - flavan-3-ols
KW  - A-type proanthocyanidins
KW  - phenolic metabolites
KW  - antiadhesive activity
KW  - probiotics
KW  - anthocyanin
KW  - tobacco-specific nitrosamine
KW  - carcinogenesis
KW  - cell proliferation
KW  - cancer chemoprevention
KW  - lung cancer
KW  - chalcones
KW  - DNA damage
KW  - anticancer activity
KW  - canine cancer cell lines
KW  - angiogenesis
KW  - in-vivo angiogenesis
KW  - CAM assay
KW  - SAR
KW  - n/a
KW  - cognition
KW  - passive avoidance test
KW  - memory extinction
KW  - mice
KW  - microglia
KW  - neuroprotection
KW  - black rice cyanidin-3-O-glucoside
KW  - wood sterols
KW  - dyslipidemia
KW  - CVD
N1  - Open Access
N2  - Flavonoids are ubiquitously present in plant-based foods and natural health products. The molecule of flavonoids is characterized by a 15-carbon skeleton of C6-C3-C6, with the different structural configuration of subclasses. The major subclasses of flavonoids with health-promotional properties are the flavanols or catechins (e.g., epigallocatechin 3-gallate from green tea), the flavones (e.g., apigenin from celery), the flavonols (e.g., quercetin glycosides from apples, berries, and onion), the flavanones (e.g., naringenin from citrus), the anthocyanins (e.g., cyanidin-3-O-glucoside from berries), and the isoflavones (e.g., genistein from soya beans). Scientific evidence has strongly shown that regular intake of dietary flavonoids in efficacious amounts reduces the risk of oxidative stress- and chronic inflammation-mediated pathogenesis of human diseases such as cardiovascular disease, certain cancers, and neurological disorders. The physiological benefits of dietary flavonoids have been demonstrated to be due to multiple mechanisms of action, including regulating redox homeostasis, epigenetic regulations, activation of survival genes and signaling pathways, regulation of mitochondrial function and bioenergetics, and modulation of inflammation response. The role of flavonoids on gut microbiota and the impact of microbial metabolites of flavonoids on optimal health has begun to unravel. The complex physiological modulations of flavonoid molecules are due to their structural diversity. However, some flavonoids are not absorbed well, and their bioavailability could be enhanced through structural modifications and applications of nanotechnology, such as encapsulation. This Special Issue consists of four review articles on flavonoids and 15 original research articles, which cover the latest findings on the role of dietary flavonoids and their derivatives in disease prevention and treatment
UR  - https://mdpi.com/books/pdfview/book/3542
UR  - https://directory.doabooks.org/handle/20.500.12854/68521
ER  -