TY  - GEN
AU  - Brüssow,Harald
TI  - Hurdles for Phage Therapy (PT) to Become a Reality
SN  - books978-3-03921-392-4
PY  - 2019///
PB  - MDPI - Multidisciplinary Digital Publishing Institute
KW  - alginate
KW  - abortive infection
KW  - n/a
KW  - bacterial resistance
KW  - bacteriophages
KW  - ATMP
KW  - MALDI-MS
KW  - adaptation
KW  - Bacteriophage
KW  - horizontal gene transfer
KW  - adaptive immunity
KW  - co-evolution
KW  - Listeria ivanovii
KW  - personalised medicines
KW  - pH stability
KW  - phage-human host interaction
KW  - vB_SauM-fRuSau02
KW  - antimicrobial resistance
KW  - phagodisinfection
KW  - biofilm
KW  - capsule depolymerase
KW  - animal model
KW  - phage cocktails
KW  - Enterococcus
KW  - cases report
KW  - zoonosis
KW  - resistance
KW  - magistral formula
KW  - experimental therapy
KW  - Belgium
KW  - phage therapy
KW  - E. faecalis
KW  - nontraditional antibacterial
KW  - industrial phage application
KW  - Democratic Republic of the Congo
KW  - OrthoMCL
KW  - Germany
KW  - high-throughput sequencing
KW  - antimicrobial
KW  - infection
KW  - antibiotic therapy
KW  - Kayvirus
KW  - phages
KW  - Twortlikevirus
KW  - bacterial disease
KW  - human host
KW  - Pseudomonas aeruginosa
KW  - phage
KW  - multidrug-resistant bacteria
KW  - bacterial infection
KW  - Salmonella Typhi
KW  - rhamnopolysaccharide
KW  - compassionate use
KW  - crop production
KW  - compounding pharmacy
KW  - antimicrobial resistance (AMR)
KW  - best practices
KW  - bacteriophage efficacy
KW  - phage sensitivity
KW  - antibiotic-resistance
KW  - antibiotic
KW  - lysins
KW  - PTMP
KW  - Escherichia coli
KW  - typhoid fever
KW  - patent landscape
KW  - phage preparation
KW  - innate immunity
KW  - anti-phage antibodies
KW  - immunology
KW  - Staphylococcus aureus
KW  - global health
KW  - clinical trial
KW  - adsorption
KW  - Brussels
KW  - phage-resistance
KW  - Galleria mellonella
KW  - science communication
KW  - history of science
KW  - virus-host interactions
KW  - foodborne illness
KW  - prophage
KW  - resistance management
KW  - biofilms
KW  - IND
KW  - immunomodulation
KW  - frequency of resistance
KW  - capsule
KW  - gastrointestinal tract
KW  - phage-host interactions
KW  - disinfection
KW  - production
KW  - bacteriophage therapy
KW  - bacteriophage
KW  - Staphylococcus
KW  - magistral preparation
KW  - extended-spectrum beta lactamases (ESBL)
KW  - Viral proteins
KW  - antibiotic resistance
KW  - genomics
KW  - phage biocontrol
KW  - therapy
KW  - target selection
KW  - viral genomes
KW  - evolution
KW  - pharmaceutical paradigm shift
KW  - personalized medicine
KW  - pharmaceutical legislation
KW  - food safety
KW  - regulation
KW  - virulence
KW  - developing countries
KW  - infectious disease
KW  - regulatory framework
KW  - sustainable agriculture
KW  - Klebsiella pneumoniae
N1  - Open Access
N2  - Alternative treatment modes for antibiotic-resistant bacterial pathogens have become a public health priority. Bacteriophages are bacterial viruses that infect and lyse bacterial cells. Since bacteriophages are frequently bacterial host species-specific and can often also infect antibiotic-resistant bacterial cells, they could represent ideal antimicrobials for fighting the antibiotic resistance crisis. The medical use of bacteriophages has become known as phage therapy. It is widely used in Russia, where phage cocktails are sold in pharmacies as an over-the-counter drug. However, no phage product has been registered for medical purposes outside of the former Soviet Union. The current Special Issue of Viruses contains a collection of papers from opinion leaders in the field who explore hurdles to the introduction of phage therapy in western countries. The articles cover diverse topics ranging from patent to regulatory issues, the targeting of suitable bacterial infections, and the selection and characterization of safe and efficient phage cocktails. Phage resistance is discussed, and gaps in our knowledge of phage-bacterium interactions in the mammalian body are revealed, while other articles explore the use of phages in food production and processing
UR  - https://mdpi.com/books/pdfview/book/1504
UR  - https://directory.doabooks.org/handle/20.500.12854/49693
ER  -