TY  - GEN
AU  - Lee,Hye Suk
AU  - Liu,Kwang-Hyeon
TI  - Drug Metabolism, Pharmacokinetics and Bioanalysis
SN  - books978-3-03897-917-3
PY  - 2019///
PB  - MDPI - Multidisciplinary Digital Publishing Institute
KW  - human liver microsomes
KW  - alcohol addiction
KW  - UGT
KW  - ultra-high-pressure liquid chromatography
KW  - adalimumab
KW  - procainamide
KW  - LC-MS/MS
KW  - DA-9805
KW  - paeonol
KW  - LC-QTOF-MS/MS
KW  - YRA-1909
KW  - chlorogenic acid
KW  - immunoprecipitation
KW  - Eurycoma longifolia
KW  - CYP
KW  - caffeic acid
KW  - rat
KW  - pharmaceutical excipient
KW  - Korean red ginseng extract
KW  - Stauntonia hexaphylla leaf extract
KW  - bioanalysis
KW  - HPLC-MS/MS
KW  - B6
KW  - eurycomanone
KW  - bioavailability
KW  - drying technology
KW  - GB3
KW  - diclofenac
KW  - 129-Glatm1Kul/J
KW  - aglycone
KW  - caffeic acid O-glucuronides
KW  - organic anion transporting polypeptide
KW  - protein precipitation
KW  - metabolic stability
KW  - Fabry disease
KW  - biopharmaceuticals
KW  - imperatorin
KW  - neochlorogenic acid
KW  - gastric ulcer
KW  - saikosaponin a
KW  - hair
KW  - anthraquinone
KW  - acetyl tributyl citrate
KW  - pharmacokinetics
KW  - brain distribution
KW  - mematine
KW  - ethyl glucuronide
KW  - pharmacokinetic
KW  - loxoprofen
KW  - liquid chromatography-quadrupole TOF MS
KW  - glucuronidation
KW  - esomeprazole
KW  - metformin
KW  - cytochrome P450
KW  - glycoside
KW  - AUDIT score
KW  - protein stability
KW  - efficacy
KW  - LC-HR/MS
KW  - cryptochlorogenic acid
KW  - aceclofenac
KW  - drug interaction
KW  - liquid chromatography-tandem mass spectrometry
KW  - Osthenol
KW  - plasma
KW  - N-acetylprocainamide
KW  - diabetes
N1  - Open Access
N2  - Drug metabolism/pharmacokinetics and drug interaction studies have been extensively carried out in order to secure the druggability and safety of new chemical entities throughout the development of new drugs. Recently, drug metabolism and transport by phase II drug metabolizing enzymes and drug transporters, respectively, as well as phase I drug metabolizing enzymes, have been studied. A combination of biochemical advances in the function and regulation of drug metabolizing enzymes and automated analytical technologies are revolutionizing drug metabolism research. There are also potential drug-drug interactions with co-administered drugs due to inhibition and/or induction of drug metabolic enzymes and drug transporters. In addition, drug interaction studies have been actively performed to develop substrate cocktails that do not interfere with each other and a simultaneous analytical method of substrate drugs and their metabolites using a tandem mass spectrometer. This Special Issue has the aim of highlighting current progress in drug metabolism/pharmacokinetics, drug interactions, and bioanalysis
UR  - https://mdpi.com/books/pdfview/book/1337
UR  - https://directory.doabooks.org/handle/20.500.12854/45509
ER  -