TY  - GEN
AU  - Silva,Rui  F.M.
AU  - Pogačnik,Lea
AU  - Silva,Rui  F.M.
AU  - Pogačnik,Lea
TI  - Dietary Polyphenols and Neuroprotection
SN  - books978-3-0365-2882-3
PY  - 2022///
CY  - Basel
PB  - MDPI - Multidisciplinary Digital Publishing Institute
KW  - Medicine
KW  - bicssc
KW  - Neurosciences
KW  - oxidative stress
KW  - ROS
KW  - neurodegenerative diseases
KW  - red grape polyphenol extract
KW  - white grape seed polyphenol extract
KW  - MecobalActive®
KW  - Olews®
KW  - Polygonum cuspidatum
KW  - Reynoutria
KW  - invasive species
KW  - phenolic compounds
KW  - flavan-3-ols
KW  - stilbenes
KW  - vitamin C
KW  - size-exclusion chromatography
KW  - DPPH test
KW  - DPPH derivatization
KW  - functional magnetic resonance imaging
KW  - spectroscopy
KW  - 7T
KW  - polyphenols
KW  - nutraceuticals
KW  - antioxidants
KW  - biosensors
KW  - xanthine oxidase
KW  - teas
KW  - drugs
KW  - ampelopsin A
KW  - Vitis vinifera
KW  - memory behavioral tests
KW  - long-term potentiation
KW  - CREB/BDNF signals
KW  - EVOO polyphenols
KW  - inflammation
KW  - ALS
KW  - FTD
KW  - neurodegeneration
KW  - resveratrol
KW  - curcumin
KW  - catechin
KW  - EGCG
KW  - epigallocatechin-3-gallate
KW  - insulin-degrading enzyme
KW  - aggregation
KW  - amyloid-beta
KW  - insulin
KW  - flavones
KW  - inhibition
KW  - autoxidation
KW  - n/a
N1  - Open Access
N2  - As editors of this book our aim was to collect new data from experienced authors in order to further advance the knowledge on the protective effects of polyphenols' intake, e.g., when included in the human diet, to modulate cellular functions and pathways associated with neurodegenerative diseases.Fruits and vegetables are the richest source of polyphenols in the regular human diet. Most of these molecules possess high antioxidant capacity, as well as several other important activities that can affect human health, among which anti-inflammatory properties and the potential ability to modulate different cell-signalling pathways seem to be the most important. Neurodegenerative diseases are among the main causes of death worldwide and, in most of them like Alzheimer's or Parkinson's, neurodegeneration occurs long before the onset of first symptoms, where a large population of brain neurons are already lost. Besides neurons, glial cells like astrocytes and microglia, are involved in oxidative and neuroinflammatory pathological pathways, making them interesting targets for neuroprotective strategies. Polyphenols are promising candidates for those strategies, either as prophylactic substances or as therapeutic molecules.In this book, several research papers and two reviews explore the chemical properties of naturally occurring polyphenols and some new possibilities for the therapeutical and/or prophylactic roles of these molecules on neurodegeneration and neurodegenerative diseases
UR  - https://mdpi.com/books/pdfview/book/4881
UR  - https://directory.doabooks.org/handle/20.500.12854/78787
ER  -