TY  - GEN
AU  - Nicolau Beckmann
AU  - Albert D.Windhorst
AU  - Igor A.Kaltashov
TI  - In Vivo Imaging in Pharmacological Research
SN  - 978-2-88945-237-8
PY  - 2017///
PB  - Frontiers Media SA
KW  - magnetic resonance imaging (MRI)
KW  - computerized tomography(CT)
KW  - positron emission tomography (PET)
KW  - pharmacology
KW  - single photon emission computed tomography (SPECT)
KW  - imaging
KW  - medical imaging
KW  - ultrasound
N1  - Open Access
N2  - The discovery and development of a biological active molecule with therapeutic properties is an ever increasing complex task, highly unpredictable at the early stages and marked, in the end, by high rates of failure. As a consequence, the overall process leading to the production of a successful drug is very costly. The improvement of the net outcome in drug discovery and development would require, amongst other important factors, a good understanding of the molecular events that characterize the disease or pathology in order to better identify likely targets of interest, to optimize the interaction of an active agent (small molecule or macromolecule of natural or synthetic origin) with those targets, and to facilitate the study of the pharmacokinetics, pharmacodynamics and toxicity of an active agent in suitable models and in human subjects. The objective of this Research Topic is to highlight new developments and applications of imaging techniques with the objective of performing pharmacological studies in vivo, in animal models and in humans. In the domain of drug discovery, the pharmacological and biomedical questions constitute the center of attention. In this sense, it is fundamental to keep in mind the strengths and limitations of each analytical or imaging technique. At the end, the judicious application of the technique with the aim of supporting the search for answers to manifold questions arising during a long and painstaking path provides a continuous role for imaging within the complex area of drug discovery and development
UR  - http://journal.frontiersin.org/researchtopic/3194/in-vivo-imaging-in-pharmacological-research
UR  - https://directory.doabooks.org/handle/20.500.12854/50092
ER  -