TY  - GEN
AU  - Robert Marr
AU  - Eliezer Masliah
TI  - Amyloid-beta clearance in Alzheimer's disease
SN  - 978-2-88919-443-8
PY  - 2015///
PB  - Frontiers Media SA
KW  - amyloid-beta
KW  - Signal Transduction
KW  - Proteases
KW  - LDL receptors
KW  - Clearance
KW  - Alzheimer's disease
N1  - Open Access
N2  - Strong evidence continues to accumulate indicating that amyloid-beta (Aß) is a central part of Alzheimer's disease (AD) pathogenesis in spite of the negative evidence coming from failed clinical trials. Therefore, mechanisms of clearance of Aß are of great interest in understanding AD pathogenesis and the development of effective treatments. This topic focuses on the issues related to Aß clearance in AD. The topics covered include proteases that degrade Aß and their localization, regulation, and functions. This topic also covers issues related to clearance through uptake by glia and through low-density lipoprotein (LDL) receptor mediated mechanisms. Signal transduction related to AD pathology and clearance is also addressed. Finally, immunotherapy and other novel therapeutic approaches are discussed
UR  - http://journal.frontiersin.org/researchtopic/2235/amyloid-beta-clearance-in-alzheimers-disease
UR  - https://directory.doabooks.org/handle/20.500.12854/40785
ER  -