TY  - GEN
AU  - Johansson,Anders
AU  - Johansson,Anders
TI  - Periodontitis : From Dysbiotic Microbial Immune Response to Systemic Inflammation
SN  - books978-3-03943-508-1
PY  - 2020///
CY  - Basel, Switzerland
PB  - MDPI - Multidisciplinary Digital Publishing Institute
KW  - Medicine
KW  - bicssc
KW  - apical periodontitis
KW  - adaptive immunity
KW  - saliva
KW  - serum
KW  - antibody
KW  - Aggregatibacter actinomycetemcomitans
KW  - invasiveness
KW  - leukotoxin
KW  - cytolethal distending toxin
KW  - serum resistance
KW  - outer membrane vesicles
KW  - oral microbiome
KW  - nitric oxide
KW  - nitrate
KW  - nitrite
KW  - periodontal disease
KW  - alveolar bone loss
KW  - gingiva
KW  - bacteria
KW  - biofilm
KW  - immunity
KW  - inflammation
KW  - smoking
KW  - Rheumatoid arthritis
KW  - Porphyromonas gingivalis
KW  - periodontitis
KW  - citrullination
KW  - peptidylarginine deiminase
KW  - ACPA
KW  - anti-CCP
KW  - host response
KW  - infection
KW  - oral microbiota
KW  - virulence factors
KW  - metabolites
KW  - TREM-1
KW  - intervention
KW  - LP17
KW  - IL-17
KW  - RANKL
KW  - OPG
KW  - cardiovascular diseases
KW  - rheumatoid arthritis
KW  - inflammatory response
N1  - Open Access
N2  - Periodontitis is an infection-induced inflammatory disease accounting for huge healthcare costs and socio-economic impacts. Bacteria from the indigenous oral flora colonize the interspace between the tooth and the connective tissue, which induces an inflammatory response. If the bacteria proliferate and release virulence factors, they cause an imbalance in the host inflammatory response that induces degenerative processes in the surrounding tissues. This process is often slow, and the disease affects mainly older people, but the process could be rapid and affect young individuals if certain pathogens colonize the area. The two most studied periodontal pathogens, Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans, express virulence factors, including proteases and exotoxins. Periodontal bacteria and their products can be translocated to the peripheral circulation and are therefore linked to the risk pattern of several systemic diseases. However, it is not known if the increased risk for systemic disease associated with periodontitis is an effect of the invading bacteria and/or their released products, the release of components from the local inflammatory response, or a common host susceptibility pattern. The most studied periodontitis-associated systemic diseases are cardiovascular diseases and rheumatoid arthritis. Here, we want to shed light on mechanisms behind the associations of periodontal infections with systemic inflammation
UR  - https://mdpi.com/books/pdfview/book/3087
UR  - https://directory.doabooks.org/handle/20.500.12854/69297
ER  -