TY  - GEN
AU  - Madureira,Patrícia Alexandra Saraiva
AU  - Madureira,Patrícia Alexandra Saraiva
TI  - The Shaping of Cancer by the Tumour Microenvironment and Its Relevance for Cancer Therapy
SN  - books978-3-0365-1607-3
PY  - 2021///
CY  - Basel, Switzerland
PB  - MDPI - Multidisciplinary Digital Publishing Institute
KW  - Medicine
KW  - bicssc
KW  - hypoxia
KW  - macrophages
KW  - colon cancer
KW  - tumor microenvironment
KW  - immune cell infiltration
KW  - prognosis
KW  - feline mammary carcinoma
KW  - PD-1
KW  - PD-L1
KW  - CTLA-4
KW  - TNF-α
KW  - biomarkers
KW  - immunotherapy
KW  - cancer
KW  - histone modification
KW  - inhibitor
KW  - KDM5B
KW  - molecular docking
KW  - repurposing
KW  - cancer acidity
KW  - hyperosmolarity
KW  - cross-presentation
KW  - tumour microenvironment
KW  - syngeneic model
KW  - prostate cancer
KW  - radiotherapy
KW  - preclinical modelling
KW  - myeloid-derived suppressor cells
KW  - biomarker
KW  - stroma
KW  - cancer-associated fibroblast (CAF)
KW  - extracellular matrix (ECM)
KW  - cytokine/chemokine
KW  - growth factors
KW  - pro- and anti-tumor immune cells
KW  - immunomodulatory roles
KW  - radiotherapy dose fractionation
KW  - radioresistance
KW  - radiosensitivity
KW  - breast cancer
KW  - S100A10 (p11)
KW  - tumor growth
KW  - tumor progression
KW  - metastasis
KW  - carcinoma
KW  - mammary gland
KW  - triple negative
KW  - pre-metastatic niche
KW  - pro-inflammatory cytokines
KW  - clinical trials
KW  - evolutionary therapy
KW  - darwinian evolution
KW  - cancer cells subpopulations
KW  - diclofenac
KW  - koningic acid
KW  - spheroid
KW  - 3D co-culture
KW  - microenvironment
KW  - resistance
KW  - myeloid cells
KW  - cancer development
KW  - molecular subtypes of pancreatic cancer
KW  - chemotherapy response
KW  - pancreatic stellate cells
KW  - regulatory T cells
KW  - tumor-associated macrophages
KW  - myeloid derived suppressor cells
KW  - glioblastoma (GB)
KW  - Hypoxia Inducible Factor (HIF)
KW  - glioma stem cells (GSC)
KW  - oxidative stress
KW  - reactive oxygen species
KW  - plasmin
KW  - plasminogen
KW  - S100A10
KW  - uPA
KW  - uPAR
KW  - PAI-1
KW  - PAI-2
KW  - cancer stem cells
KW  - cancer recurrence
KW  - therapeutic resistance
KW  - signaling pathways
KW  - targeted therapy
KW  - head and neck cancer
KW  - lung cancer
KW  - bladder cancer
N1  - Open Access
N2  - In this book, we present a compilation of original research articles as well as review articles that are focused on improving our understanding of the molecular and cellular mechanisms by which cancer cells adapt to their microenvironment. These include the interplay between cancer cells and the surrounding microenvironmental cells (e.g., macrophages, tumor-infiltrating lymphocytes and myeloid cells) and microenvironmental environments (e.g., oxidative stress, pH, hypoxia) and the implications of this dynamic interaction to tumor radioresistance, chemoresistance, invasion and metastasis. Finally, the importance and relevance of these findings are translated to cancer therapy
UR  - https://mdpi.com/books/pdfview/book/4271
UR  - https://directory.doabooks.org/handle/20.500.12854/76822
ER  -