TY  - GEN
AU  - Ishigami,Tomoaki
AU  - Ishigami,Tomoaki
TI  - Ubiquitination in Health and Diseases
SN  - books978-3-0365-0547-3
PY  - 2021///
CY  - Basel, Switzerland
PB  - MDPI - Multidisciplinary Digital Publishing Institute
KW  - Humanities
KW  - bicssc
KW  - Social interaction
KW  - deubiquitinase
KW  - degradation
KW  - therapeutic target
KW  - cancer
KW  - hematopoiesis
KW  - hematopoietic stem cells
KW  - immune response
KW  - regulation of gene expression
KW  - ubiquitin system
KW  - genetic diseases
KW  - ubiquitin ligase
KW  - deubiquitinases
KW  - monoubiquitin signaling
KW  - vesicular trafficking
KW  - protein complex formation
KW  - inflammation
KW  - inhibitor
KW  - innate immune
KW  - interferon
KW  - LUBAC
KW  - NF-κB
KW  - ubiquitin
KW  - Parkinson's disease
KW  - dopa-responsive dystonia
KW  - tyrosine hydroxylase
KW  - α-synuclein
KW  - fatty acid-binding protein 3
KW  - ubiquitination
KW  - proteasomal degradation
KW  - ubiquitin-proteasome system
KW  - mitochondria
KW  - E3 ubiquitin ligase
KW  - MITOL/MARCH5
KW  - salt-sensitive hypertension
KW  - Nedd4L/Nedd4-2
KW  - epithelial sodium channel
KW  - aldosterone sensitive distal nephron
KW  - excitation-transcription coupling
KW  - RNF183
KW  - RNF186
KW  - RNF182
KW  - RNF152
KW  - RING finger
KW  - mTOR
KW  - endoplasmic reticulum stress
KW  - osmotic stress
KW  - ubiquitin code
KW  - virus infection
KW  - virus-host interaction
KW  - tau protein
KW  - semisynthesis
KW  - disulfide-coupling
KW  - polyubiquitin
KW  - fibrils
KW  - aggregation
KW  - neurodegeneration
KW  - deubiquitination
KW  - inhibitors
KW  - protein quality control
KW  - proteolysis
KW  - protein stabilization
KW  - regulatory T cells
KW  - mesenchymal stem cell
KW  - cortical bone derived stem cell
KW  - myocardial infarction
KW  - blood pressure
KW  - renal salt reabsorption
KW  - vascular function
KW  - ubiquitin proteasome system
KW  - ubiquitin-proteasome pathway
KW  - cilia
KW  - ciliogenesis
KW  - differentiation
KW  - proliferation
KW  - ciliopathy
KW  - E3s
KW  - DUBs
KW  - UPS
KW  - neurodegenerative disease
KW  - immune-related diseases
N1  - Open Access
N2  - Ubiquitination is a biological process mediated by ubiquitin itself, the E1 ubiquitin-activating enzyme, E2 ubiquitin-conjugating enzyme, E3 ubiquitin ligase, and deubiquitinating enzyme, respectively. Currently, these multiple biological steps are revealed to participate in various life phenomena, such as cell proliferation, regulation of cell surface proteins expression, and mitochondrial function, which are profoundly related to human health and diseases. Although clinical applications targeting ubiquitination are still limited compared to those directed toward kinase systems such as tyrosine kinases, multiple enzymatic consequences should be future therapeutic implications. This Special Issue of IJMS entitled "Ubiquitination in Health and Disease" successfully published15 distinguished manuscripts, with a total of 66 international authors and. This book provides the latest and most useful information for researchers and scientists in this field
UR  - https://mdpi.com/books/pdfview/book/3729
UR  - https://directory.doabooks.org/handle/20.500.12854/76311
ER  -