TY  - GEN
AU  - Burri,Christian
AU  - Burri,Christian
TI  - Human African Trypanosomiasis (Sleeping Sickness) : The Road to Elimination Revisited-Achievements and Remaining Challenges
SN  - books978-3-03928-964-6
PY  - 2020///
CY  - Basel, Switzerland
PB  - MDPI - Multidisciplinary Digital Publishing Institute
KW  - Medicine
KW  - bicssc
KW  - Epidemiology & medical statistics
KW  - (+)-spectaline
KW  - iso-6-spectaline
KW  - Trypanosoma brucei rhodesiense
KW  - autophagy
KW  - apoptosis
KW  - cross-talk
KW  - trypanosomosis
KW  - iron
KW  - transferrin
KW  - transferrin receptor
KW  - nutritional immunity
KW  - flagellar pocket
KW  - Human African Trypanosomiasis (HAT)
KW  - mydriasis
KW  - neurological signs
KW  - eradication
KW  - re-emergence
KW  - human African trypanosomiasis
KW  - treatment
KW  - melarsoprol
KW  - adverse event
KW  - encephalopathy
KW  - human leukocyte antigen
KW  - association study
KW  - disease elimination
KW  - disease eradication
KW  - frontline workers
KW  - DR Congo
KW  - mobile screening
KW  - qualitative methods
KW  - sequelae
KW  - serology
KW  - oligosymptomatic HAT
KW  - product development partnerships
KW  - research and development
KW  - medical innovation
KW  - donor policy
KW  - African trypanosomiasis
KW  - sleeping sickness
KW  - trypanosoma brucei
KW  - drugs
KW  - drug resistance
KW  - history
KW  - human Africa trypanosomiasis
KW  - fexinidazole
KW  - home-based treatment
KW  - patient-centred care
KW  - Uganda
KW  - elimination
KW  - T. b. gambiense
KW  - g-HAT
KW  - T. b. rhodesiense
KW  - r-HAT
KW  - neglected tropical diseases
KW  - Trypanosoma brucei
KW  - drug discovery
KW  - high-throughput screening
KW  - blood-brain barrier
KW  - brain permeability
KW  - pharmacology
KW  - phenotypic drug screening
KW  - Haemoparasites
KW  - animal reservoirs
KW  - Trypanosoma growth inhibitors
KW  - chemotherapy
KW  - pafuramidine
KW  - acoziborole
KW  - African sleeping sickness
KW  - development of treatment
KW  - suramin
KW  - medical history
KW  - political history
KW  - clinical research
KW  - health system strengthening
KW  - South Sudan
KW  - diagnosis
KW  - symptoms
KW  - treatment-seeking
KW  - case detection
KW  - embodiment
KW  - expertise
KW  - serendipity
KW  - CATT positive serological suspects
KW  - active follow-up strategy
KW  - n/a
N1  - Open Access
N2  - As it is a goal to eliminate human African trypanosomiasis (HAT; sleeping sickness) as a public health problem by 2020 and interrupt transmission by 2030, this is a good moment to reflect on what we have achieved, what we want to achieve, and what could get in our way. HAT has a reputation for spectacular reappearances, and the latest peak of 40,000 reported and over 300,000 estimated cases only dates back to 1998. Efforts of the WHO and partners as well as the development of simpler and much better-tolerated treatments, improved diagnostics, and vector control tools made it possible to reduce this number by 95%. Case identification and confirmation remain complex and require specific skills, treatment remains error-prone and reports on long-term survivors have emerged, and the relevance of the animal reservoir for T. b. gambiense HAT needs clarification. In addition, to win the "end game" against this massively stigmatized disease, the human factor will play a key role. This Special Issue addresses many of the burning topics about disease elimination in its 12 research and 7 review articles and one case study. The papers critically reflect the approaches used, investigate the mentioned challenges, and propose novel approaches and interventions from various points of view
UR  - https://mdpi.com/books/pdfview/book/2386
UR  - https://directory.doabooks.org/handle/20.500.12854/68624
ER  -