TY  - GEN
AU  - Cavallaro,Ugo
AU  - Giordano,Marco
AU  - Cavallaro,Ugo
AU  - Giordano,Marco
TI  - New Aspects of Cancer Stem Cell Biology : Implications for Innovative Therapies
SN  - books978-3-03943-407-7
PY  - 2020///
CY  - Basel, Switzerland
PB  - MDPI - Multidisciplinary Digital Publishing Institute
KW  - Research & information: general
KW  - bicssc
KW  - Biology, life sciences
KW  - Cadherin 11
KW  - WNT signaling
KW  - β-catenin
KW  - cancer stem cells
KW  - TNBC
KW  - early breast cancer
KW  - bevacizumab
KW  - neoadjuvant chemotherapy
KW  - ALDH1
KW  - solid cancer
KW  - chemo-resistance
KW  - HDAC inhibitors
KW  - head and neck squamous cell carcinoma
KW  - SRC
KW  - dasatinib
KW  - saracatinib
KW  - EC-8042
KW  - Ovarian cancer
KW  - Wnt signaling
KW  - tumor progression
KW  - therapy resistance
KW  - exosomes
KW  - oral cancer risk
KW  - oral epithelial dysplasia
KW  - SOX2
KW  - immunohistochemistry
KW  - oral squamous cell carcinoma
KW  - genome-wide
KW  - transcriptome
KW  - lung cancer
KW  - ATAC-seq
KW  - RNA-seq
KW  - CSCs
KW  - NSCLC
KW  - B4GALT1
KW  - LUAD
KW  - breast cancer
KW  - lipid
KW  - metabolism
KW  - therapeutic resistance
KW  - bowel cancer
KW  - organoid
KW  - tumoroid
KW  - colorectal
KW  - colon
KW  - stem cell
KW  - chemotherapy resistance
KW  - ovarian cancer
KW  - cancer stem cell
KW  - genetic heterogeneity
KW  - SNP array
KW  - L1CAM
KW  - chemoresistance
KW  - epithelial-mesenchymal transition
KW  - cancer therapy
KW  - cell adhesion molecule
N1  - Open Access
N2  - The cancer stem cell (CSC) paradigm represents one of the most prominent breakthroughs of the last decades in tumor biology. CSCs are that subpopulation within a tumor that can survive conventional therapies and as a consequence are able to fuel tumor recurrence. Nevertheless, the biological characteristics of CSCs and even their existence, remain the main topic among tumor biologists debates. The difficulty in achieving a better definition of CSC biology may actually be explained by the plasticity of such a cell subpopulation. Indeed, the emerging view is that CSCs represent a dynamic "state" of tumor cells that can acquire stemness-related properties under specific circumstances, rather than referring to a well-defined group of cells. Regardless of their origin, it is clear that designing novel antitumor treatments based on the eradication of CSCs will only be possible upon unraveling the biological mechanisms that underlie their pathogenic role in tumor progression and therapy resistance. The Special Issue on "New aspects of cancer stem cell biology: implications for innovative therapies" aims at highlighting recent insights into CSC features that can make them an attractive target for novel therapeutic strategies
UR  - https://mdpi.com/books/pdfview/book/3120
UR  - https://directory.doabooks.org/handle/20.500.12854/69328
ER  -