TY  - GEN
AU  - Viseras,César
AU  - Viseras,César
TI  - Clay-Based Pharmaceutical Formulations and Drug Delivery Systems
SN  - books978-3-0365-0187-1
PY  - 2021///
CY  - Basel, Switzerland
PB  - MDPI - Multidisciplinary Digital Publishing Institute
KW  - Medicine
KW  - bicssc
KW  - hydrochlorothiazide
KW  - cyclodextrins
KW  - sepiolite
KW  - nanoclay
KW  - dissolution rate
KW  - tablet
KW  - electrospinning
KW  - chitosan
KW  - chondroitin sulfate
KW  - scaffolds
KW  - montmorillonite
KW  - halloysite
KW  - fibroblasts proliferation
KW  - immune response
KW  - glycosaminoglycans
KW  - antimicrobial properties
KW  - palygorskite
KW  - spring water
KW  - hydrogel
KW  - fibroblast
KW  - biocompatibility
KW  - wound healing
KW  - mesoporous clay
KW  - Neusilin
KW  - aeroperl
KW  - liquisolid technique
KW  - glyburide
KW  - dissolution improvement
KW  - hydrotalcite
KW  - ketoprofen
KW  - hybrid
KW  - photostability
KW  - hydrogel film
KW  - bioadhesion
KW  - heavy metal
KW  - hazardous element
KW  - element mobility
KW  - clay minerals
KW  - toxicity
KW  - palygorksite
KW  - proliferation
KW  - Franz cell
KW  - bioactive elements
KW  - praziquantel
KW  - drug
KW  - organic solvents
KW  - in vitro dissolution tests
KW  - cytotoxicity
KW  - targeted drug delivery
KW  - halloysite nanotube
KW  - osteosarcoma
KW  - methotrexate
KW  - surface modification
KW  - n/a
N1  - Open Access
N2  - This book includes recent advances in the use of clays in the design of medicinal products and medicinal devices. The pharmaceutical applications of nanoclays are far ranging, because of their distinct advantages: they are versatile (possess a wide range of mechanical, chemical and physical properties) and available at reasonable costs. Some special clays (mainly kaolinite, halloysite, montmorillonite, saponite, hectorite, palygorskite and sepiolite), as well as semi-synthetic (organoclays) or synthetic (double layer hydroxides) derivatives, are very useful materials for modulating drug delivery. In the last decade, several actives have been loaded onto nanoclays and similar inorganic excipients to increase solubility, improve stability, reduce toxicity, and enhance bioavailability, with a consequent increase in therapeutic response. Polymer/clay nanocomposites with synergic properties have been developed, showing improved mechanical properties with respect to the pristine polymer matrices and allowing modified release of loaded actives. Moreover, nanoclays have very recently demonstrated positive effects on the proliferation and migration of fibroblasts. The development of clay-based medicinal products and medicinal devices requires experience in the fields of both clay structure and properties and pharmaceutical technology design
UR  - https://mdpi.com/books/pdfview/book/3321
UR  - https://directory.doabooks.org/handle/20.500.12854/68311
ER  -