TY  - GEN
AU  - Gonzalez-Alvarez,Maria Isabel
AU  - Dahan,Arik
AU  - Gonzalez-Alvarez,Maria Isabel
AU  - Dahan,Arik
TI  - Regional Intestinal Drug Absorption : Biopharmaceutics and Drug Formulation
SN  - books978-3-0365-3657-6
PY  - 2022///
CY  - Basel
PB  - MDPI - Multidisciplinary Digital Publishing Institute
KW  - Medicine
KW  - bicssc
KW  - Pharmaceutical industries
KW  - bioequivalence
KW  - Biopharmaceutics Classification System
KW  - in vitro
KW  - dissolution test
KW  - pravastatin
KW  - oral absorption
KW  - in silico modeling
KW  - GastroPlus
KW  - Phoenix WinNonlin
KW  - pharmacokinetics
KW  - clinical studies
KW  - ibuprofen
KW  - manometry
KW  - gastrointestinal
KW  - mechanistic modeling
KW  - PBPK
KW  - PBBM
KW  - disintegration
KW  - dissolution
KW  - enteric-coated
KW  - ICH
KW  - quality control
KW  - regional intestinal permeability
KW  - permeation enhancers
KW  - absorption-modifying excipients
KW  - oral peptide delivery
KW  - intestinal perfusion
KW  - pharmaceutical development
KW  - controlled release drug product
KW  - biopharmaceutics classification system
KW  - drug solubility
KW  - drug permeability
KW  - location-dependent absorption
KW  - segregated flow intestinal model (SFM)
KW  - traditional model (TM)
KW  - route-dependent intestinal metabolism
KW  - first-pass effect
KW  - drug-drug interactions
KW  - DDI
KW  - in vitro in vivo extrapolations
KW  - IVIVE
KW  - zero-order absorption
KW  - first-order absorption
KW  - combined zero- and first-order absorption
KW  - transit compartment absorption model
KW  - in situ perfusion
KW  - microdevices
KW  - shape
KW  - mucoadhesion
KW  - colon absorption
KW  - nutrient digestion
KW  - nutrient absorption
KW  - gastrointestinal hormone
KW  - postprandial glycaemia
KW  - energy intake
KW  - region of the gut
KW  - obesity
KW  - type 2 diabetes
KW  - Franz-PAMPA
KW  - BCS drugs
KW  - biomimetic membrane
KW  - Franz cell
KW  - passive drug transport
KW  - BCS class IV drugs
KW  - segmental-dependent intestinal permeability
KW  - intestinal absorption
KW  - oral drug delivery
KW  - biopharmaceutics
KW  - physiologically-based pharmacokinetic (PBPK) modeling
KW  - furosemide
KW  - intestinal permeability
KW  - human colon carcinoma cell layer (Caco-2)
KW  - hierarchical support vector regression (HSVR)
KW  - drug absorption
KW  - drug solubility/dissolution
KW  - regional/segmental-dependent permeability and absorption
N1  - Open Access
N2  - The gastrointestinal tract (GIT) can be broadly divided into several regions: the stomach, the small intestine (which is subdivided to duodenum, jejunum, and ileum), and the colon. The conditions and environment in each of these segments, and even within the segment, are dependent on many factors, e.g., the surrounding pH, fluid composition, transporters expression, metabolic enzymes activity, tight junction resistance, different morphology along the GIT, variable intestinal mucosal cell differentiation, changes in drug concentration (in cases of carrier-mediated transport), thickness and types of mucus, and resident microflora. Each of these variables, alone or in combination with others, can fundamentally alter the solubility/dissolution, the intestinal permeability, and the overall absorption of various drugs. This is the underlying mechanistic basis of regional-dependent intestinal drug absorption, which has led to many attempts to deliver drugs to specific regions throughout the GIT, aiming to optimize drug absorption, bioavailability, pharmacokinetics, and/or pharmacodynamics. In the book "Regional Intestinal Drug Absorption: Biopharmaceutics and Drug Formulation" we aim to highlight the current progress and to provide an overview of the latest developments in the field of regional-dependent intestinal drug absorption and delivery, as well as pointing out the unmet needs of the field
UR  - https://mdpi.com/books/pdfview/book/5393
UR  - https://directory.doabooks.org/handle/20.500.12854/81051
ER  -