TY  - GEN
AU  - Tzanakakis,George
AU  - Nikitovic,Dragana
AU  - Tzanakakis,George
AU  - Nikitovic,Dragana
TI  - The Role of Extracellular Matrix in Cancer Development and Progression
SN  - books978-3-0365-3406-0
PY  - 2022///
CY  - Basel
PB  - MDPI - Multidisciplinary Digital Publishing Institute
KW  - Research & information: general
KW  - bicssc
KW  - elastin
KW  - ribosomal protein SA
KW  - tongue carcinoma
KW  - MMP-2
KW  - EGCG
KW  - pancreatic ductal adenocarcinoma
KW  - syndecans
KW  - proteoglycans
KW  - tumor progression
KW  - angiogenesis
KW  - syndecan-4
KW  - heparan sulfate
KW  - cancer
KW  - prognosis
KW  - biomarker
KW  - signal transduction
KW  - proteoglycan
KW  - metastasis
KW  - extracellular matrix
KW  - fibrosis
KW  - immune cell modulation
KW  - neutrophils
KW  - neutrophil extracellular trap
KW  - macrophages
KW  - BCC
KW  - MMP
KW  - TIMP
KW  - invasion
KW  - lumican
KW  - cancer cell growth
KW  - motility
KW  - hyaluronan
KW  - RHAMM
KW  - CD44
KW  - wound repair
KW  - breast cancer
KW  - malignant pleural mesothelioma
KW  - pleural effusion
KW  - extracellular vesicles
KW  - biomarkers
KW  - sulfated hyaluronan
KW  - estrogen receptors
KW  - epithelial-to-mesenchymal transition
KW  - matrix metalloproteinases
KW  - n/a
N1  - Open Access
N2  - The extracellular matrix (ECM) scaffold, which surrounds and supports the cells in tissues, consists of fibrillar proteins, proteoglycans, glycosaminoglycans, signaling molecules, and enzymes involved in its remodeling. The stages of cancer progression, e.g., local invasion, intravasation, extravasation, distant invasion and immunosuppression, are obligatorily perpetrated through interactions of these tumor cells with the ECM. Cancer-related ECM changes can be exploited for the evaluation of disease progression, anticancer therapy development, and monitoring of therapy response. Thus, in breast cancer, hyaluronan-mediated wound repair mechanisms are hijacked to promote tumor development. Altered mechanical properties of the pancreatic cancer ECM are immunosuppressive and prevent the penetration of cytotoxic chemotherapy agents. The expression of the proteoglycan syndecan-4 is modulated by anticancer drugs, suggesting its potential druggabilty capacity. Another proteoglycan, lumican, is proposed as a cancer prognosis marker, chemoresistance regulator, and cancer therapy target. Due to their remodeling properties, the MMPs are vital mediators and important therapeutic targets. Treatment of breast cancer cells with sulfated hyaluronan has been shown to attenuate tumor cell growth, migration, and invasion. Extracellular vesicles (EVs), comprising exosomes, microvesicles, and apoptotic bodies, are released by all cells into the ECM and body fluids and can be utilized as diagnostic markers in malignant pleural mesothelioma. These exciting developments encourage tumor biology scientists for further creative research
UR  - https://mdpi.com/books/pdfview/book/5190
UR  - https://directory.doabooks.org/handle/20.500.12854/81159
ER  -