TY  - GEN
AU  - Colpi,Giovanni M.
AU  - Caroppo,Ettore
AU  - Colpi,Giovanni M.
AU  - Caroppo,Ettore
TI  - Update on the Management of Non-Obstructive Azoospermia: Current Evidence and Unmet Needs
SN  - books978-3-0365-3434-3
PY  - 2022///
CY  - Basel
PB  - MDPI - Multidisciplinary Digital Publishing Institute
KW  - Medicine
KW  - bicssc
KW  - Pharmacology
KW  - nonobstructive azoospermia
KW  - micro-TESE
KW  - FSH treatment
KW  - hormonal treatment
KW  - testosterone level
KW  - microdissection testicular sperm extraction
KW  - non-obstructive azoospermia
KW  - management
KW  - infertility
KW  - intracytoplasmic sperm injection
KW  - testicular azoospermia
KW  - sperm selection
KW  - sperm
KW  - cryopreservation
KW  - in vitro maturation
KW  - azoospermia
KW  - diagnosis
KW  - male infertility
KW  - spermatogenic failure
KW  - testis biopsy
KW  - sperm retrieval
KW  - genetic testing
KW  - endocrine evaluation
KW  - review
KW  - hypogonadism
KW  - Sertoli cell-only syndrome
KW  - testicular spermatozoa
KW  - processing
KW  - microfluidics
KW  - new technologies
KW  - genetics
KW  - exome
KW  - WES
KW  - Y chromosome
KW  - cancer
KW  - NOA
KW  - genes
KW  - general health
KW  - ICSI
KW  - offspring health
KW  - microTESE
KW  - prediction model
KW  - n/a
N1  - Open Access
N2  - Azoospermia, defined as the absence of sperm in the ejaculate after examination of the centrifuged specimens, affects about 1% of the male population and 10-15% of infertile men. In about two-thirds of cases, this is caused by severe spermatogenic dysfunction, and it is commonly termed "nonobstructive azoospermia" (NOA) to differentiate it from the less severe form of azoospermia caused by the obstruction of the seminal tract (obstructive azoospermia-OA), the latter affecting the remaining one-third of cases. Managing patients with NOA is challenging due to the severity of spermatogenic dysfunction and the lack of medical treatments, with surgical retrieval of testicular sperm being the only way of enabling some of these patients to father their own biological children. In-depth clinical knowledge is key for supporting clinical reasoning and decision making when counselling patients with NOA, and surgical skill is required to maximize the outcome of surgical procedures that aim to retrieve testicular sperm. The present book is a collection of scientific papers published in a Special Issue of the Journal of Clinical Medicine, authored by some of the most influential researchers in the field. The Special Issue, and thus also this book, were conceived to provide early career reproductive urologists and endocrinologists with an update of the scientific evidence in the field, together with surgical tips
UR  - https://mdpi.com/books/pdfview/book/5167
UR  - https://directory.doabooks.org/handle/20.500.12854/81136
ER  -