TY - GEN AU - Jankowski,Joachim AU - Noels,Heidi AU - Jankowski,Joachim AU - Noels,Heidi TI - Comorbidities in Chronic Kidney Disease (CKD) SN - books978-3-03936-669-9 PY - 2021/// CY - Basel, Switzerland PB - MDPI - Multidisciplinary Digital Publishing Institute KW - Medicine KW - bicssc KW - arterial stiffness KW - carotid-femoral pulse wave velocity KW - hemodialysis KW - p-cresyl sulfate KW - uremic toxins KW - arterial calcification KW - lipid metabolism KW - inflammation KW - coagulation KW - endothelial dysfunction KW - epigenetics KW - chronic kidney disease KW - uremic cardiopathy KW - left ventricular hypertrophy KW - phosphate KW - PTH KW - FGF23 KW - klotho KW - sclerostin KW - chronodisruption KW - chronodisruptor KW - circadian rhythm KW - internal clock KW - uremia KW - uremic cardiomyopathy KW - organ crosstalk KW - cardiorenal syndrome KW - left-ventricular hypertrophy KW - heart failure KW - cardiac fibrosis KW - cardiovascular disease KW - vascular calcification KW - experimental rodent models KW - FGFG23 KW - Klotho KW - Wnt/β-catenin KW - CKD KW - parathyroid hormone KW - secondary hyperparathyroidism KW - uremic toxin KW - ageing KW - end-stage kidney disease KW - premature ageing KW - senescence KW - bone KW - gut KW - cardiovascular KW - CKD-MBD KW - comorbidity KW - fibrosis KW - calcification N1 - Open Access N2 - With a mean worldwide prevalence of 13%, chronic kidney disease imposes a massive health burden on our society. In addition to reduced kidney function, patients with chronic kidney disease increasingly suffer from cardiovascular diseases affecting the heart and vasculature. Cardiovascular diseases account for around half of the deaths of patients with advanced chronic kidney disease. However, therapeutic options are highly insufficient. The pathological mechanisms that underlie increased cardiovascular risk in patients with chronic kidney disease remain largely unknown. This Special Issue provides insights into comorbidities in CKD patients, mainly focused on increased cardiovascular risk, and summarizes current knowledge of underlying pathophysiological mechanisms UR - https://mdpi.com/books/pdfview/book/3437 UR - https://directory.doabooks.org/handle/20.500.12854/68421 ER -