TY  - GEN
AU  - Ey,Elodie
AU  - Bourgeron,Thomas
AU  - Maria Boeckers,Tobias
AU  - Kim,Eunjoon
AU  - Han,Kihoon
AU  - Ey,Elodie
AU  - Bourgeron,Thomas
AU  - Maria Boeckers,Tobias
AU  - Kim,Eunjoon
AU  - Han,Kihoon
TI  - Shankopathies: Shank Protein Deficiency-Induced Synaptic Diseases
SN  - 978-2-88963-567-2
PY  - 2020///
PB  - Frontiers Media SA
KW  - Science: general issues
KW  - bicssc
KW  - Neurosciences
KW  - Shank
KW  - Shankopathies
KW  - neuropsychiatric disorders
KW  - modulating factors
KW  - brain regions
N1  - Open Access
N2  - Shank (also known as ProSAP) is a family of postsynaptic scaffolding proteins that are thought to be involved in the regulation of excitatory synapse development, function, and plasticity. The Shank family contains three known members (Shank1, Shank2, and Shank3). These proteins are equipped with various domains for protein-protein interactions known to mediate direct and indirect interactions with many other synaptic proteins, including glutamate receptors, other synaptic scaffolding proteins, and signaling molecules. Importantly, Shank has been implicated in diverse neuropsychiatric disorders, including autism spectrum disorders, schizophrenia, and Phelan-McDermid syndrome, a form of developmental delay and intellectual disability. The mechanisms underlying these abnormalities, collectively termed "Shankopathies," are being actively investigated, although overall progress has been slow for many reasons
UR  - https://www.frontiersin.org/research-topics/6607/shankopathies-shank-protein-deficiency-induced-synaptic-diseases#overview
UR  - https://directory.doabooks.org/handle/20.500.12854/73719
ER  -