TY  - GEN
AU  - Rovina,Nikoletta
AU  - Rovina,Nikoletta
TI  - Asthma : Current Perspectives on Phenotypes, Endotypes, and Treatable Traits
SN  - books978-3-03943-860-0
PY  - 2021///
CY  - Basel, Switzerland
PB  - MDPI - Multidisciplinary Digital Publishing Institute
KW  - Medicine
KW  - bicssc
KW  - asthma
KW  - lactic acidosis
KW  - hyperchloremic acidosis
KW  - hypocapnia
KW  - hypercapnia
KW  - wheezing
KW  - bronchial biopsies
KW  - symptom persistence
KW  - clinical remission
KW  - eosinophil
KW  - adhesion
KW  - viability
KW  - proliferation
KW  - airway smooth muscle cell
KW  - pulmonary fibroblast
KW  - phenotype
KW  - acute severe asthma exacerbation
KW  - near fatal asthma
KW  - severe asthma
KW  - inflammation
KW  - interleukin-5 (IL-5)
KW  - anti-IL-5
KW  - interleukin-4
KW  - airway remodeling
KW  - matrix metalloproteinases-9
KW  - tissue inhibitor of metalloproteinase-1
KW  - alveolar macrophages
KW  - lung function
KW  - bronchodilation
KW  - resistance
KW  - obstruction
KW  - reproducible
KW  - spirometry
KW  - obstructive sleep apnea
KW  - bronchial asthma
KW  - alternative overlap syndrome
KW  - exacerbation
KW  - reactive oxygen species
KW  - PBMC
KW  - mitochondrial function
KW  - innate immunity
KW  - immune regulation
KW  - NLRP3
KW  - IL-1β
KW  - allergic airway inflammation
KW  - microbiome
KW  - pathogenesis
KW  - immune responses
KW  - PreDicta
KW  - preschool
KW  - FeNO
KW  - asthma-specific quality of life
KW  - chronic rhinitis
KW  - disease-specific quality of life
KW  - health-related quality of Life (HRQLQ)
KW  - children
KW  - longitudinal study
N1  - Open Access
N2  - Asthma is a common complex and heterogeneous respiratory disease with an increasing prevalence in developed countries. Asthma is a disease consisting of different phenotypes that are driven by different mechanistic pathways (endotypes). The recognition of these phenotypes and endotypes is central to asthma management entailing prognostic and therapeutic implications. It is acknowledged that despite optimal treatment, many patients are poorly controlled, highlighting the need for phenotype-guided treatments. In this context, the emergence of novel therapies (monoclonal antibody therapy, bronchial thermoplasty) is paving the way for personalized asthma therapy. A better understanding of disease pathogenesis may enable the identification of biomarkers, mediators, novel therapeutic targets, and treatable traits. Further molecular phenotyping or endotyping of asthma will be necessary to tailor new therapeutic strategies. The present Special Issue on Asthma aims to provide the current knowledge on phenotypes and endotypes in appreciating and managing the heterogeneous condition that is asthma
UR  - https://mdpi.com/books/pdfview/book/3288
UR  - https://directory.doabooks.org/handle/20.500.12854/68279
ER  -