TY  - BOOK
AU  - Mushegian,Arcady R.
TI  - Foundations of comparative genomics
SN  - 9780120887941
AV  - QH447 .M88 2007eb
U1  - 572.8/6 22
PY  - 2007///
CY  - Amsterdam, Boston
PB  - Academic Press
KW  - Genomics
KW  - Gene mapping
KW  - Physiology, Comparative
KW  - Genetics
KW  - Technique
KW  - methods
KW  - Genetic Techniques
KW  - Sequence Analysis
KW  - Chromosome Mapping
KW  - Génomique
KW  - Cartes chromosomiques
KW  - Physiologie comparée
KW  - Génétique
KW  - SCIENCE
KW  - Life Sciences
KW  - Genetics & Genomics
KW  - bisacsh
KW  - fast
KW  - Electronic books
N1  - Includes bibliographical references (pages 238-257) and index; The beginning of computational genomics -- Finding sequence similarities -- Homology: can we get it right? -- Getting ready for the era of comparative genomics: the importance of viruses -- The first fact of comparative genomics: protein sequences are remarkably resilient in evolution -- The second fact of comparative genomics: functional convergence at the molecular level -- Prediction of function and reconstruction of metabolism from genomic data: homology-based approaches -- Prediction of function and reconstruction of metabolism: post-homology approaches -- Structural genomics: what does it tell us about life? -- How many protein families are there? -- Phylogenetic inference and the era of complete genomes -- Two stories about evolution -- Minimal and ancestral genomes -- Comparative genomics and systems biology
N2  - This book provides an overview of computational analysis of genes and genomes, and of some most notable findings that come out of this work. Foundations of Comparative Genomics presents a historical perspective, beginning with early analysis of individual gene sequences, to present day comparison of gene repertoires encoded by completely sequenced genomes. The author discusses the underlying scientific principles of comparative genomics, argues that completion of many genome sequences started a new era in biology, and provides a personal view on several state-of-the-art issues, such as systems biology and whole-genome phylogenetic reconstructions. This book is an essential reference for researchers and students in computational biology, evolutionary biology, and genetics. * Presents an historic overview of genome biology and its achievements * Includes topics not covered in other books such as minimal and ancestral genomes * Discusses the evolutionary resilience of protein-coding genes and frequent functional convergence at the molecular level * Critically reviews horizontal gene transfer and other contentious issues * Covers comparative virology as a somewhat overlooked foundation of modern genome science
UR  - https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=199143
ER  -